151900-33-3

Basic information

• Product Name: 1,1-diethyloxy-3-(4-chlorophenyl)urea
• Synonyms: 1,1-diethyloxy-3-(4-chlorophenyl)urea
• CAS NO: 151900-33-3
• Molecular Weight: 258.705
• Mol File: 151900-33-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,1-diethyloxy-3-(4-chlorophenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-diethyloxy-3-(4-chlorophenyl)urea(151900-33-3)
• EPA Substance Registry System: 1,1-diethyloxy-3-(4-chlorophenyl)urea(151900-33-3)

Safety Data

• Hazardous Substances Data: 151900-33-3(Hazardous Substances Data)

Upstream product

• 942296-13-1 ethyl (D-erythro)-3-(4-chlorophenylcarbamoyloxy)-2,2-difluoro-3-(2,2-dimethyl-dioxalane-4-yl)propionate 

Relevant articles and documents

PROCESS FOR PREPARING GEMCITABINE AND ASSOCIATED INTERMEDIATES

Provided is a process for preparing gemcitabine and intermediates useful in the production of gemcitabine. Exemplary intermediates include mixtures of D-erythro and D-threo diastereomers of ethyl 3-(N-carbamoyloxy)-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)propionates, from which a preferred isomer can be separated, e.g., by selective crystallization, in accordance with the invention. Also provided are novel alkyl (D-erythro)-3-hydroxy-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)propionate intermediates, and novel ribo lactones, which can be used for producing gemcitabine.