151917-39-4

Basic information

• Product Name: 6-Iodopyridine-3-carboxylic acid ethyl ester
• Synonyms: 6-Iodopyridine-3-carboxylic acid ethyl ester;6-Iodo-nicotinic acid ethyl ester;Ethyl 6-iodonicotinate
• CAS NO: 151917-39-4
• Molecular Formula: C₈H₈INO₂
• Molecular Weight: 277.05909
• Mol File: 151917-39-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 6-Iodopyridine-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Iodopyridine-3-carboxylic acid ethyl ester(151917-39-4)
• EPA Substance Registry System: 6-Iodopyridine-3-carboxylic acid ethyl ester(151917-39-4)

Safety Data

• Hazardous Substances Data: 151917-39-4(Hazardous Substances Data)

Usage

General Description

6-Iodopyridine-3-carboxylic acid ethyl ester is a chemical compound with the molecular formula C8H8INO2. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 6-Iodopyridine-3-carboxylic acid ethyl ester is a derivative of pyridine and contains both iodine and ethyl ester functional groups. It can be used in the production of various drugs and medical compounds due to its high reactivity and ability to undergo a variety of chemical reactions. Additionally, it is also used as a building block in organic synthesis and can be employed in the development of new molecules for medicinal and industrial purposes.

Upstream product

• 13054-02-9 6-iodo-nicotinic acid 
• 541-41-3 chloroformic acid ethyl ester 
• 64-17-5 ethanol 
• 78-39-7 Triethyl orthoacetate 

Downstream Products

• 176088-50-9 4-(8,8-dimethyl-5-oxo-5,6,7,8-tetrahydronaphthalene-2-yl-ethynyl)-benzoic acid ethyl ester 
• 176088-52-1 Ethyl 6-[(5,6,7,8-tetrahydro-8,8-dimethyl-5-oxonaphth-2-yl)ethynyl]nicotinate 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 1762-46-5 [2,2']bipyridinyl-5,5'-dicarboxylic acid diethyl ester 
• 59-67-6 nicotinic acid 
• 1174028-84-2 6-phenylethynyl-nicotinic acid ethyl ester 
• 120972-91-0 5-(hydroxymethyl)-2-iodopyridine 
• 220882-43-9 ethyl 2-ethynylpyridine-5-carboxylate 
• 173156-98-4 (3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl) (5-carboxypyrid-2-yl)sulfide 

Relevant articles and documents

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Evaluation of radiolabeled (Hetero)aromatic analogues of N-(2-diethylaminoethyl)-4-iodobenzamide for imaging and targeted radionuclide therapy of melanoma

Targeted radionuclide therapy using radioiodinated compounds with a specific affinity for melanoma tissue is a promising treatment for disseminated melanoma, but the candidate with the ideal kinetic profile remains to be discovered. Targeted radionuclide therapy concentrates the effects on tumor cells, thereby increasing the efficacy and decreasing the morbidity of radiotherapy. In this context, analogues of N-(2-diethylaminoethyl)-4- iodobenzamide (BZA) are of interest. Various (hetero)aromatic analogues 5 of BZA were synthesized and radioiodinated with 125I, and their biodistribution in melanoma-bearing mice was studied after i.v. administration. Most [125I]5-labeled compounds appeared to bind specifically and with moderate-to-high affinity to melanoma tumor. Two compounds, 5h and 5k, stood out with high specific and long-lasting uptake in the tumor, with a 7- and 16-fold higher value than BZA at 72 h, respectively, and kinetic profiles that makes them promising agents for internal targeted radionuclide therapy of melanoma.

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