152121-41-0

Basic information

• Product Name: 1-(4-Fluorophenyl)-2-(4-pyridinyl)-1,2-ethanedione
• Synonyms: 1-(4-Fluorophenyl)-2-(4-pyridinyl)-1,2-ethanedione;(4-Fluorophenyl)-4-pyridinyl-ethanedione;1-(4-Fluorophenyl)-2-(4-pyridyl)ethanedial
• CAS NO: 152121-41-0
• Molecular Formula: C₁₃H₈FNO₂
• Molecular Weight: 229.2065232
• Product Categories: Aromatics;Heterocycles;Intermediates;Aromatics, Heterocycles, Intermediates
• Mol File: 152121-41-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 384.041°C at 760 mmHg
• Flash Point: 186.061°C
• Appearance: /
• Density: 1.289g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.582
• Solubility: Acetone, Chloroform, Methanol
• CAS DataBase Reference: 1-(4-Fluorophenyl)-2-(4-pyridinyl)-1,2-ethanedione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Fluorophenyl)-2-(4-pyridinyl)-1,2-ethanedione(152121-41-0)
• EPA Substance Registry System: 1-(4-Fluorophenyl)-2-(4-pyridinyl)-1,2-ethanedione(152121-41-0)

Safety Data

• Hazardous Substances Data: 152121-41-0(Hazardous Substances Data)

Usage

Description

1-(4-Fluorophenyl)-2-(4-pyridinyl)-1,2-ethanedione is an organic compound characterized by its yellow solid appearance. It is a chemical intermediate that plays a significant role in the synthesis of various chemical compounds, particularly substituted imidazoles.

Uses

1. Used in Pharmaceutical Industry:
1-(4-Fluorophenyl)-2-(4-pyridinyl)-1,2-ethanedione is used as a chemical intermediate for the preparation of substituted imidazoles, which are important in the development of pharmaceutical compounds. The application reason is that these substituted imidazoles can exhibit a range of biological activities, making them valuable in the creation of new drugs for various medical conditions.
2. Used in Chemical Synthesis:
In the field of chemical synthesis, 1-(4-Fluorophenyl)-2-(4-pyridinyl)-1,2-ethanedione serves as a key building block for the synthesis of more complex organic molecules. The application reason is its unique structure, which allows for further functionalization and the creation of a diverse array of chemical products with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C13H8FNO2/c14-11-3-1-9(2-4-11)12(16)13(17)10-5-7-15-8-6-10/h1-8H

Upstream product

• 6576-05-2 1-(4-fluorophenyl)-2-(4-pyridyl)ethanone 
• 152121-40-9 1-(4-fluorophenyl)-2-pyridin-4-ylethane-1,2-diol 
• 115858-98-5 1-(4-fluorophenyl)-2-(pyridin-4-yl)-2-ethanone 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 108-89-4 picoline 

Downstream Products

• 1191272-27-1 3-(4-fluorophenyl)-6-methoxy-2-(pyridin-4-yl)quinoxaline 
• 1207531-68-7 2-(4-fluorophenyl)-6-methoxy-3-(pyridin-4-yl)quinoxaline 
• 1207531-65-4 2-(4-fluorophenyl)-3-(pyridin-4-yl)quinoxaline 
• 1207532-01-1 2-(4-fluorophenyl)-3-(pyridin-4-yl)pyrido[4,3-b]pyrazine 
• 1207531-97-2 3-(4-fluorophenyl)-2-(pyridin-4-yl)pyrido[3,4-b]pyrazine 
• 1207532-00-0 2-(4-fluorophenyl)-3-(pyridin-4-yl)pyrido[2,3-b]pyrazine 
• 1207531-96-1 3-(4-fluorophenyl)-2-(pyridin-4-yl)pyrido[2,3-b]pyrazine 
• 181630-93-3 4-(4-Fluorophenyl)-5-(pyridin-4-yl)-1H-imidazole 

Relevant articles and documents

The anion of 3-methyl-2-pyridin-4-yl-1,3-oxazine

n-Butyllithium at -78°C readily abstracts the methine proton from the title compound. The anion reacts efficiently with a range of electrophiles to provide 4-pyridyl ketones upon acid hydrolysis.

Role of the hydrogen bonding heteroatom-lys53 interaction between the p38r mitogen-activated protein (map) kinase and pyridinyl-substituted 5-membered heterocyclic ring inhibitors

In the framework of investigating the role of heteroatoms in pyridinyl-substituted 5-membered (hetero)cycles as potential p38α MAP kinase inhibitor scaffolds, cyclopentene, pyrrole, furan, and imidazole analogues were synthesized and tested with respect t

Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents

Several analogs of 2,3-diaryl pyrroles were synthesized and evaluated as inhibitors of Eimeria tenella cGMP-dependent protein kinase and in in vivo anticoccidial assays. A 4-fluorophenyl group enhances both in vitro and in vivo activities. The most potent