152148-79-3

Basic information

• Product Name: (3-hydroxy-4-nitro-phenyl)-acetic acid
• Synonyms: (3-hydroxy-4-nitro-phenyl)-acetic acid
• CAS NO: 152148-79-3
• Molecular Weight: 197.147
• Mol File: 152148-79-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (3-hydroxy-4-nitro-phenyl)-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3-hydroxy-4-nitro-phenyl)-acetic acid(152148-79-3)
• EPA Substance Registry System: (3-hydroxy-4-nitro-phenyl)-acetic acid(152148-79-3)

Safety Data

• Hazardous Substances Data: 152148-79-3(Hazardous Substances Data)

Usage

Description

(3-hydroxy-4-nitro-phenyl)-acetic acid is a chemical compound with the molecular formula C8H7NO5. It is a derivative of acetic acid with a hydroxy and a nitro group attached to a phenyl ring. (3-hydroxy-4-nitro-phenyl)-acetic acid is known for its versatile reactivity and functional groups, making it a valuable building block in the synthesis of various pharmaceuticals and organic compounds. Additionally, it has been studied for its potential biological activities and pharmacological properties, highlighting its importance in the field of chemistry and medicine.

Uses

Used in Pharmaceutical Synthesis:
(3-hydroxy-4-nitro-phenyl)-acetic acid is used as a building block for the synthesis of various pharmaceuticals and organic compounds. Its unique structure and functional groups allow for the creation of a wide range of molecules with different therapeutic properties.
Used in Chemical Research:
In the field of chemical research, (3-hydroxy-4-nitro-phenyl)-acetic acid is utilized for studying its potential biological activities and pharmacological properties. This helps in understanding its possible applications in medicine and the development of new drugs.
Used in Organic Chemistry:
(3-hydroxy-4-nitro-phenyl)-acetic acid is also used in organic chemistry for the synthesis of various organic compounds. Its versatile reactivity allows for the formation of different chemical bonds and the creation of a diverse range of molecules.

Upstream product

• 441713-49-1 diethyl 2-(3-(benzyloxy)-4-nitrophenyl)malonate 
• 621-37-4 m-hydroxyphenylacetic acid 
• 26386-82-3 5-(bromomethyl)-2-nitrophenol 
• 61161-83-9 5-(hydroxymethyl)-2-nitrophenol 
• 957273-65-3 (3-Hydroxy-4-nitro-phenyl)-acetonitrile 

Downstream Products

• 256453-84-6 2-(3-hydroxy-4-nitrophenyl)acetic acid methyl ester 
• 133331-79-0 4-amino-3-hydroxyphenylacetic acid 
• 301810-30-0 (3-acetoxy-4-nitro-phenyl)acetic acid 

Relevant articles and documents

Reduction of the nitro group to amine by hydroiodic acid to synthesize o-aminophenol derivatives as putative degradative markers of neuromelanin

Neuromelanin (NM) is produced in dopaminergic neurons of the substantia nigra (SN) and in noradrenergic neurons of the locus coeruleus (LC). The synthesis of NM in those neurons is a component of brain aging and there is the evidence that this pigment can be involved in the pathogenesis of neurodegenerative diseases such as Parkinson's disease. NM is believed to derive from the oxidative polymerization of dopamine (DA) or norepinephrine (NE) with the participation of cysteine, dolichols and proteins. However, there are still unknown aspects in the chemical structure of NM from SN (SN-NM) and LC (LC-NM). In this study, we designed a new method to synthesize o-aminophenol compounds as putative degradation products of catecholamines and their metabolites which may be incorporated into NM. Those compounds are aminohydroxyphenylethylamine (AHPEA) isomers, aminohydroxyphenylacetic acid (AHPAA) isomers and aminohydroxyethylbenzene (AHEB) isomers, which are expected to arise from DA or NE, 3,4-dihydroxyphenylacetic acid (DOPAC) or 3,4-dihydroxyphenylmandelic acid (DOMA) and 3,4-dihydroxyphenylethanol (DOPE) or 3,4- dihydroxyphenylethyleneglycol (DOPEG), respectively. These o-aminophenol compounds were synthesized by the nitration of phenol derivatives followed by reduction with hydroiodic acid (HI), and they could be identified by HPLC in HI hydrolysates of SN-NM and LC-NM. This degradative approach by HI hydrolysis allows the identification of catecholic precursors unique to SN-NM and LC-NM, which are present in catecholaminergic neurons.

VLA-4 INHIBITORS

The present invention relates to a compound represented by the following formula (I): (wherein, W represents WA-A1 -WB - (in which, WA is substituted or unsubstituted aryl, etc., A1 is -NR1-, single bond, -C(O)-, etc., and WB is substituted or unsubstituted arylene, etc.), R is single bond, -NH-, -OCH2-, alkenylene, etc., X is -C(O) -CH2-, etc., and M is, for example, the following formula: (in which, R11, R12 and R13 each independently represents hydrogen, hydroxyl, amino, halogen, etc., R14 is hydrogen or lower alkyl, Y represents -CH2-O-, etc., Z is substituted or unsubstituted arylene, etc., A2 is single bond, etc, and R10 is hydroxyl or lower alkoxy)), or salt thereof; and a medicament containing the same. This compound or salt thereof selectively inhibits binding of cell adhesion molecules to VAL-4 and exhibits high bioavailability so that it is useful as a preventive and/or remedy for inflammatory diseases, autoimmune diseases, metastasis, bronchial asthma, rhinostenosis, diabetes, and the like.

Structure-activity studies for a novel series of N-(arylethyl)-N- (1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-N-methylamines possessing dual 5- HT uptake inhibiting and α2-antagonistic activities

In search of an α2-antagonist/5-HT uptake inhibitor as a potential new class of antidepressant with a more rapid onset of action, compound 3 was prepared and observed to possess high affinity for the α2-receptor (K(i) = 6.71 nM) and