15220-11-8 Usage
Description
4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT, also known as MUS, is a synthetic compound commonly used as a fluorimetric substrate for various enzymes. It is a crystalline solid that exhibits unique chemical properties, such as a shift in the excitation wavelength of the umbelliferone upon substitution of the hydroxyl group. 4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT is virtually non-fluorescent until cleaved by specific enzymes, after which it emits blue fluorescence.
Uses
Used in Enzyme Assays:
4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT is used as a fluorimetric substrate for the determination of arylsulphatase enzyme activity. The compound's fluorescence properties make it an ideal candidate for monitoring enzyme activity in various biological samples.
Used in Neurochemistry:
In the field of neurochemistry, MUS is utilized as a Met-enkephalin analog found in opioid extracts of brain and adrenal chromaffin cells. It serves as an artifact generated by trichloroacetic acid extraction, contributing to the understanding of opioid systems in the brain.
Used in Drug Discovery:
4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT is used as a fluorometric substrate in the discovery of tyrosine sulfotransferase inhibitors, particularly in P-selectin glycoprotein ligand-1 binding. The compound's fluorescence emission upon enzyme cleavage aids in the identification of potential inhibitors that can modulate tyrosine sulfotransferase activity.
Used in High-Throughput Screening:
In the pharmaceutical industry, 4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT is used as a substrate for high-throughput fluorescence-based screening. This application has led to the discovery of several potent beta-arylsulfotransferase IV (beta-AST-IV) inhibitors, which are crucial for drug development and understanding enzyme functions.
Used in Research and Development:
4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT is employed in research and development for the study of sulfatase enzymes and their role in various biological processes. The compound's unique fluorescence properties make it a valuable tool for investigating enzyme mechanisms, substrate specificity, and potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 15220-11-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,2,2 and 0 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 15220-11:
(7*1)+(6*5)+(5*2)+(4*2)+(3*0)+(2*1)+(1*1)=58
58 % 10 = 8
So 15220-11-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H8O6S.K/c1-6-4-10(11)15-9-5-7(2-3-8(6)9)16-17(12,13)14;/h2-5H,1H3,(H,12,13,14);/q;+1/p-1/rC10H7KO6S/c1-6-4-10(12)15-9-5-7(2-3-8(6)9)16-18(13,14)17-11/h2-5H,1H3
