152397-54-1 Usage
Description
(1S,3R,20S)-1,3-bis(tert-butyldimethylsilyloxy)-20-(3-hydroxy-3-methylbuthyloxy)pregn-5-ene is a synthetic derivative of pregn-5-ene, a steroid hormone. It features a 27-carbon backbone and incorporates various functional groups, such as tert-butyldimethylsilyloxy and hydroxyalkoxy groups. This complex molecule is characterized by its specific arrangement of functional groups and stereochemistry.
Uses
Used in Organic Synthesis:
(1S,3R,20S)-1,3-bis(tert-butyldimethylsilyloxy)-20-(3-hydroxy-3-methylbuthyloxy)pregn-5-ene is utilized as a building block in organic synthesis for the creation of other steroid compounds. Its unique functional groups and stereochemistry make it a key intermediate in the production of various biologically active steroids and related compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 152397-54-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,2,3,9 and 7 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 152397-54:
(8*1)+(7*5)+(6*2)+(5*3)+(4*9)+(3*7)+(2*5)+(1*4)=141
141 % 10 = 1
So 152397-54-1 is a valid CAS Registry Number.
152397-54-1Relevant articles and documents
Industrial synthesis of maxacalcitol, the antihyperparathyroidism and antipsoriatic vitamin D3 analogue exhibiting low calcemic activity
Shimizu, Hitoshi,Shimizu, Kazuki,Kubodera, Noboru,Mikami, Tetsuhiro,Tsuzaki, Kaname,Suwa, Hiroyuki,Harada, Koji,Hiraide, Akira,Shimizu, Motoki,Koyama, Kaichiro,Ichikawa, Yoshihide,Hirasawa, Daisuke,Kito, Yasushi,Kobayashi, Mio,Kigawa, Masaharu,Kato, Masahiro,Kozono, Toshiro,Tanaka, Hideki,Tanabe, Makoto,Iguchi, Masanori,Yoshida, Mitsutaka
, p. 278 - 287 (2012/12/24)
Maxacalcitol, the 22-oxa-derivative of 1α,25-dihydroxyvitamin D 3 and used currently as an antihyperparathyroidism and antipsoriatic drug, has been synthesized in seven chemical steps from 1α- hydroxydehydroepiandrosterone on the basis of our previously developed route. The present synthesis allows the production of the protected form of the penultimate intermediate in 26% overall yield in a kilogram scale reaction employing neither difficult reaction conditions nor chromatographic purification, having overcome all the difficulties involved in the previous route.
