152467-43-1

Basic information

• Product Name: 1-(4-chlorophenyl)-1,3-propanediol
• CAS NO: 152467-43-1
• Molecular Weight: 186.638
• Mol File: 152467-43-1.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1-(4-chlorophenyl)-1,3-propanediol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-chlorophenyl)-1,3-propanediol(152467-43-1)
• EPA Substance Registry System: 1-(4-chlorophenyl)-1,3-propanediol(152467-43-1)

Safety Data

• Hazardous Substances Data: 152467-43-1(Hazardous Substances Data)

Upstream product

• 1073-67-2 4-vinylbenzyl chloride 
• 1798-84-1 1-chloro-4-cyclopropylbenzene 
• 99-91-2 para-chloroacetophenone 
• 22027-53-8 methyl 3-(4-chlorophenyl)-3-oxopropanoate 
• 104-88-1 4-chlorobenzaldehyde 
• 70200-14-5 ethyl 3-hydroxy-3-(4-chlorophenyl)propanoate 
• 56856-73-6 3-(4-chlorophenyl)-3-ketopropionaldehyde 
• 2881-63-2 ethyl (4-chlorobenzoyl)acetate 

Downstream Products

• 928780-22-7 4-amino-1-{3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-[4-(4-chloro-phenyl)-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yloxymethyl]-tetrahydro-furan-2-yl}-1H-pyrimidin-2-one 
• 171661-84-0 3-(4-chlorophenyl)-3-hydroxypropyl 4-methylbenzenesulfonate 
• 1621176-43-9 1-(4-chlorophenyl)-3-(4,5,6,7-tetrabromo-2H-benzotriazol-2-yl)propan-1-ol 

Relevant articles and documents

Lewis Base-Promoted Ring-Opening 1,3-Dioxygenation of Unactivated Cyclopropanes Using a Hypervalent Iodine Reagent

A facile and effective system has been developed for the regio- and chemoselective ring-opening/electrophilic functionalization of cyclopropanes through C?C bond activation by [bis(trifluoroacetoxy)iodo]benzene with the aid of the Lewis basic promoter p-toluenesulfonamide. The p-toluenesulfonamide-promoted system works well for a wide range of cyclopropanes, resulting in the formation of 1,3-diol products in good yields and regioselectivity.

Studies on the chemoenzymatic synthesis of (R)- and (S)-methyl 3-aryl-3-hydroxypropionates: The influence of toluene-pretreatment of lipase preparations on enantioselective transesterifications

Two series (para- and meta-substituted) of racemic methyl esters of 3-aryl-3-hydroxypropionic acid were prepared after which the enantiomers were separated by an enzyme-catalyzed transesterification. Several lipases were investigated as the catalyst. The influence of the enzyme pretreatment, as well as substrate concentration, reaction temperature, stirring manner, and substrate conversion on the stereochemical outcome of the biotransformation process were investigated in detail. The best results were achieved by using solvent-pretreated lipase from Pseudomonas fluorescens or Burkholderia cepacia suspended in toluene, and vinyl acetate as the acetyl group donor.

Tandem catalysis by lipase in a vinyl acetate-mediated cross-aldol reaction

The lipase Novozym435 (0.6% w/w) was used in tandem with organocatalysts in a first vinyl/isopropenyl acetate-mediated aldol reaction. The reaction was facilitated through the lipase-catalyzed in situ generation of acetaldehyde/acetone. The important features of the present methodology include the mild and facile reaction conditions, regenerability of the lipase, comparatively high yields and minimal side product formation.