152548-66-8 Usage
Description
Fmoc-N-methyl-L-aspartic acid 4-tert-butyl ester is a chemical compound that is part of the Fmoc protected N-methyl amino acid family. It is a white to off-white solid and is specifically designed for use in solid phase peptide synthesis. The compound is characterized by its ability to improve the proteolytic stability of peptides, making it a valuable component in the development of various pharmaceutical and biotechnological applications.
Uses
Used in Pharmaceutical Industry:
Fmoc-N-methyl-L-aspartic acid 4-tert-butyl ester is used as a building block for the synthesis of peptides with enhanced stability. The increased stability provided by N-methyl amino acids is crucial for the development of more effective and longer-lasting drugs, particularly in the context of proteolytic degradation.
Used in Biotechnology Industry:
In the biotechnology sector, Fmoc-N-methyl-L-aspartic acid 4-tert-butyl ester is utilized as a key component in the creation of peptides with improved resistance to enzymatic degradation. This enhanced stability is essential for the development of bioactive molecules with potential applications in various fields, such as agriculture, environmental science, and medical research.
Used in Research and Development:
Fmoc-N-methyl-L-aspartic acid 4-tert-butyl ester is employed as a research tool for the investigation of peptide structure and function. Its role in solid phase peptide synthesis allows scientists to explore the properties and potential applications of N-methyl amino acids in various biological systems, contributing to the advancement of peptide-based therapies and drug development.
Used in Drug Delivery Systems:
Fmoc-N-methyl-L-aspartic acid 4-tert-butyl ester can be used in the development of novel drug delivery systems, particularly for peptide-based drugs. The improved proteolytic stability provided by N-methyl amino acids can enhance the bioavailability and therapeutic outcomes of peptide drugs, making them more effective and reliable in treating various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 152548-66-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,2,5,4 and 8 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 152548-66:
(8*1)+(7*5)+(6*2)+(5*5)+(4*4)+(3*8)+(2*6)+(1*6)=138
138 % 10 = 8
So 152548-66-8 is a valid CAS Registry Number.
InChI:InChI=1/C24H27NO6/c1-24(2,3)31-21(26)13-20(22(27)28)25(4)23(29)30-14-19-17-11-7-5-9-15(17)16-10-6-8-12-18(16)19/h5-12,19-20H,13-14H2,1-4H3,(H,27,28)/t20-/m0/s1
152548-66-8Relevant articles and documents
Synthesis method of N-methyl-(2S)-2-N-fluorenylmethoxycarbonylamino-aspartic acid (4-tert-butyl ester)
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Paragraph 0010-0011, (2020/06/16)
The invention relates to a synthesis method of N-methyl-(2S)-2-N-fluorenylmethoxycarbonyl amino-aspartic acid (4-tert-butyl ester). The method mainly solves the technical problem of product racemization and the problem of large-scale production in the existing synthesis method. The preparation method comprises the following four steps: step 1, dissolving a raw material A in tetrahydrofuran, addingcesium carbonate and methyl iodide to obtain a compound 1, and directly applying the product to the next step of reaction without purification; 2, at room temperature, introducing hydrogen into the compound 1 to react in methanol, and carrying out palladium-carbon catalysis to obtain a compound 2; 3, dissolving the compound 2 in methyl alcohol, adding L-(-)-diacetyl tartaric acid, and carrying out salifying treatment until ee is larger than 99%, so that a compound 3 is obtained, 4, performing a reaction on the compound 3 with acetone and sodium hydroxide, adding Fmoc-OSu is added for a reaction, and performing hydrochloric acid acidification to obtain the target compound 4.
