152714-07-3

Basic information

• Product Name: 3-(4-CHLOROPHENYL)-CYCLOBUTAN-1-ONE
• Synonyms: 3-(4-CHLOROPHENYL)-CYCLOBUTAN-1-ONE;3-(4-CHLOROPHENYL)-CYCLOBUTANE-1-ONE
• CAS NO: 152714-07-3
• Molecular Formula: C₁₀H₉ClO
• Molecular Weight: 180.63
• Mol File: 152714-07-3.mol
• Article Data: 20

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-CHLOROPHENYL)-CYCLOBUTAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-CHLOROPHENYL)-CYCLOBUTAN-1-ONE(152714-07-3)
• EPA Substance Registry System: 3-(4-CHLOROPHENYL)-CYCLOBUTAN-1-ONE(152714-07-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 152714-07-3(Hazardous Substances Data)

Usage

General Description

3-(4-chlorophenyl)-cyclobutan-1-one is a chemical compound with the formula C10H11ClO. It is a cyclobutanone derivative with a 4-chlorophenyl group attached to the cyclobutanone ring. 3-(4-CHLOROPHENYL)-CYCLOBUTAN-1-ONE is often used in pharmaceutical and research applications as a building block for the synthesis of other compounds. It can also be used as a precursor in the synthesis of various drugs and organic molecules. The 4-chlorophenyl group on the cyclobutanone ring makes this compound useful for introducing specific structural and functional characteristics to other molecules, making it a valuable tool in synthetic organic chemistry. Additionally, it may have potential pharmacological and biological activities that make it of interest for further research and development.

Upstream product

• 1073-67-2 4-vinylbenzyl chloride 
• 127-19-5 N,N-dimethyl acetamide 
• 104-88-1 4-chlorobenzaldehyde 
• 152713-97-8 1-Chloro-4-(2,2-dichloro-3,3-difluoro-cyclobutyl)-benzene 
• 152714-00-6 1-Chloro-4-(2-chloro-3,3-difluoro-cyclobut-1-enyl)-benzene 
• 191019-76-8 2,2-dichloro-3-(4'-chlorophenyl)cyclobutanone 
• 76-02-8 trifluoroacetyl chloride 
• 152714-04-0 2-Chloro-3-(4-chloro-phenyl)-cyclobut-2-enone 

Downstream Products

• 89359-16-0 (S)-β-(4-chlorophenyl)-γ-butyrolactone 
• 147224-51-9 β-(R)-(p-chlorophenyl)-γ-butyrolactone 
• 1384187-21-6 3-(4-chlorophenyl)-2-(hydroxy(4-nitrophenyl)methyl)cyclobutanone 
• 1384187-26-1 3-(4-chlorophenyl)-2-((4-(trifluoromethyl)phenyl)(hydroxy)methyl)cyclobutanone 
• 1360179-96-9 C₁₉H₁₇ClO 
• 1360180-13-7 C₁₉H₁₅ClO 
• 1286795-62-7 4-(4-chlorophenyl)-5-hydroxy-1-phenylpyrrolidin-2-one 

Relevant articles and documents

A simple and efficient new approach to the total synthesis of (±)-4- amino-3-(4-chlorophenyl)-butyric acid (BACLOFEN)

Based on the utilization of a [2+21 cycloaddition reaction between dichloroketene and an appropriated olefin as a key step, we describe a new and simple four step approach to the total synthesis of (±)-4-amino-3-(4- chlorophenyl)-butyric acid (BACLOFEN),

Desymmetrization of Prochiral Cyclobutanones via Nitrogen Insertion: A Concise Route to Chiral γ-Lactams

Asymmetric access to γ-lactams is achieved via a cyclobutanone ring expansion using widely available (1S,2R)-1-amino-2-indanol for chiral induction. Mechanistic analysis of the key N,O-ketal rearrangement reveals a Curtin–Hammett scenario, which enables a downstream stereoinduction (up to 88:12 dr) and is corroborated by spectroscopic, crystallographic, and computational studies. In combination with an easy deprotection protocol, this operationally simple sequence allows the synthesis of a range of optically pure γ-lactams, including those bearing all-carbon quaternary stereocenters. In addition, the formal synthesis of drug molecules baclofen, brivaracetam, and pregabalin further demonstrates the synthetic utility and highlights the general applicability of the presented method.

CARBOXAMIDE AND SULFONAMIDE DERIVATIVES USEFUL AS TEAD MODULATORS

The invention is concerned with the compounds of formula (I) and formula (II): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of using the compounds of formula (I) and formula (II) as well as pharmaceutical compositions containing such compounds. The compounds are useful in treating diseases and conditions mediated by TEAD, such as cancer.