15288-01-4

Basic information

• Product Name: 7-hydroxy-6-methoxy-3,4-dihydronaphthalen-1(2H)-one
• CAS NO: 15288-01-4
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.2112
• Mol File: 15288-01-4.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 393°C at 760 mmHg
• Flash Point: 159.4°C
• Density: 1.238g/cm³
• Vapor Pressure: 9.72E-07mmHg at 25°C
• Refractive Index: 1.581
• CAS DataBase Reference: 7-hydroxy-6-methoxy-3,4-dihydronaphthalen-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-hydroxy-6-methoxy-3,4-dihydronaphthalen-1(2H)-one(15288-01-4)
• EPA Substance Registry System: 7-hydroxy-6-methoxy-3,4-dihydronaphthalen-1(2H)-one(15288-01-4)

Safety Data

• Hazardous Substances Data: 15288-01-4(Hazardous Substances Data)

Upstream product

• 71089-44-6 6-methoxy-7-acetoxy-1-tetralone 
• 13575-75-2 6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydronaphthalene 
• 360796-29-8 7-amino-6-methoxy-3,4-dihydro-2H-naphthalen-1-one 
• 1317-39-1 copper(I) oxide 
• 144-55-8 sodium hydrogencarbonate 
• 17212-96-3 7-Acetoxy-6-methoxy-1,2,3,4-tetrahydronaphthalene 
• 84-58-2 2,3-dicyano-5,6-dichloro-p-benzoquinone 
• 54549-75-6 6,7-dihydroxy-3,4-dihydro-1(2H)-naphthalenone 
• 74-88-4 methyl iodide 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 98799-43-0 trans-4-(3,4-dimethoxyphenyl)but-3-enoic acid 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 13575-74-1 4-(3,4-dimethoxyphenyl)butanoic acid 

Downstream Products

• 1262799-69-8 1-(4-(1-(4-fluorophenyl)-8-isopropoxy-7-methoxy-4,5-dihydro-1H-benzo[g]indazole-3-carbonyl)-1,4-diazepan-1-yl)ethanone 
• 1262799-71-2 C₂₄H₂₅FN₂O₄ 
• 1262799-72-3 C₂₂H₂₁FN₂O₄ 

Relevant articles and documents

Computational and Experimental Studies of Phthaloyl Peroxide-Mediated Hydroxylation of Arenes Yield a More Reactive Derivative, 4,5-Dichlorophthaloyl Peroxide

The oxidation of arenes by the reagent phthaloyl peroxide provides a new method for the synthesis of phenols. A new, more reactive arene oxidizing reagent, 4,5-dichlorophthaloyl peroxide, computationally predicted and experimentally determined to possess enhanced reactivity, has expanded the scope of the reaction while maintaining a high level of tolerance for diverse functional groups. The reaction proceeds through a novel "reverse-rebound" mechanism with diradical intermediates. Mechanistic insight was achieved through isolation and characterization of minor byproducts, determination of linear free energy correlations, and computational analysis of substituent effects of arenes, each of which provided additional support for the reaction proceeding through the diradical pathway.

Dihydrobenzoindazoles

The invention relates to benzoindazole derivatives according to general Formula I or a pharmaceutically acceptable salt thereof. The compounds can be used for the treatment of infertility.

Tubulin binding agents and corresponding prodrug constructs

A diverse set of tubulin binding agents have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl-aryl, pseudo pi stacking distances appropriate for molecular recognition of tubulin. In phenolic or amino form, these ligands may be further functionalized to prepare phosphate esters, phosphate salts, phosphoramidates, and other prodrugs capable of demonstrating selective targeting and destruction of tumor cell vasculature.