152943-97-0

Basic information

• Product Name: 1-(2-Methoxyphenyl)-[1,4]diazepane
• Synonyms: 1-(2-Methoxyphenyl)-[1,4]diazepane
• CAS NO: 152943-97-0
• Molecular Formula: C₁₂H₁₈N₂O
• Molecular Weight: 206.28
• Product Categories: pharmacetical
• Mol File: 152943-97-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 342.6°Cat760mmHg
• Flash Point: 161°C
• Appearance: /
• Density: 1.034g/cm³
• Vapor Pressure: 7.47E-05mmHg at 25°C
• Refractive Index: 1.524
• CAS DataBase Reference: 1-(2-Methoxyphenyl)-[1,4]diazepane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Methoxyphenyl)-[1,4]diazepane(152943-97-0)
• EPA Substance Registry System: 1-(2-Methoxyphenyl)-[1,4]diazepane(152943-97-0)

Safety Data

• Hazardous Substances Data: 152943-97-0(Hazardous Substances Data)

Usage

Chemical class

Diazepanes

Psychoactive substance

Yes

Central nervous system effects

Anxiolytic and sedative properties

Structural relation

Benzodiazepines

Potential therapeutic applications

Antidepressant and anticonvulsant

Medical use approval

Not approved in most countries

Legal status

Controlled substance

Ongoing research

Safety and potential therapeutic applications

InChI:InChI=1/C12H18N2O/c1-15-12-6-3-2-5-11(12)14-9-4-7-13-8-10-14/h2-3,5-6,13H,4,7-10H2,1H3

Upstream product

• 578-57-4 2-bromoanisole 
• 505-66-8 1,4-Diazacycloheptane 
• 112275-50-0 tert-butyl 1,4-diazepine-1-carboxylate 
• 91-16-7 1,2-dimethoxybenzene 

Downstream Products

• 1435684-52-8 4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butan-1-amine 
• 1435684-92-6 N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-4-(thiophen-3-yl)benzamide 
• 1435684-99-3 4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)benzamide 
• 1435685-06-5 N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-4-(methylthio)benzamide 
• 1435685-12-3 N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)benzofuran-2-carboxamide 
• 1435685-18-9 4-(2-fluoroethyl)-N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)benzamide 
• 1435685-24-7 N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-4-vinylbenzamide 
• 1435685-30-5 4-chloro-N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)benzamide 
• 1435685-36-1 4-fluoro-N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)benzamide 
• 1435685-42-9 N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-5-methylthiophene-2-carboxamide 
• 1435685-54-3 N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)benzo[b]thiophene-2-carboxamide 
• 1435685-60-1 N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-5-phenylthiophene-2-carboxamide 
• 1435685-66-7 4-(2-hydroxyethyl)-N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)benzamide 
• 1435685-72-5 N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)-9-oxo-9H-fluorene-4-carboxamide 

Relevant articles and documents

Identification of novel GLUT inhibitors

The compound class of 1H-pyrazolo[3,4-d]pyrimidines was identified using HTS as very potent inhibitors of facilitated glucose transporter 1 (GLUT1). Extensive structure–activity relationship studies (SAR) of each ring system of the molecular framework was established revealing essential structural motives (i.e., ortho-methoxy substituted benzene, piperazine and pyrimidine). The selectivity against GLUT2 was excellent and initial in vitro and in vivo pharmacokinetic (PK) studies are encouraging.

THIENOPYRIDINE DERIVATIVES

The present invention provides a compound promoting osteogenesis. The present invention provides a compound having the following general formula (I) wherein R 1 is H or alkyl, R 2 is R a S-, R a O-, R a NH-, R a (R b )N- or cyclic amino, and R a and R b are alkyl which may be substituted, cycloalkyl which may be substituted, or the like, or a pharmacologically acceptable salt thereof.

DIHYDROPYRIDINE NPY ANTAGONISTS: PIPERAZINE DERIVATIVES

A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of piperazine and homopiperazine derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). STR1 As antagonists of NPY-induced feeding behavior, these compounds are e