153046-00-5Relevant articles and documents
Total Synthesis of (+)-Hyacinthacine A1Using a Chemoselective Cross-Benzoin Reaction and a Furan Photooxygenation-Amine Cyclization Strategy
Parmar, Karnjit,Haghshenas, Pouyan,Gravel, Michel
, p. 1416 - 1421 (2021)
We report the shortest synthesis of glycosidase inhibitor (+)-hyacinthacine A1 using a highly chemoselective N-heterocyclic carbene-catalyzed cross-benzoin reaction as well as a furan photooxygenation-amine cyclization strategy. This is the first such cyclization on a furylic alcohol, an unprecedented reaction due to the notorious instability of the formed intermediates. The photooxygenation strategy was eventually incorporated into a three-step one-pot process that formed the requisite pyrrolizidine framework of (+)-hyacinthacine A1.
A concise stereoselective synthesis of orthogonally protected lanthionine and β-methyllanthionine
Cobb, Steven L.,Vederas, John C.
, p. 1031 - 1038 (2008/01/03)
Lantibiotics such as nisin are active against most Gram-positive bacteria and constitute an important class of antibacterial agents. These ribosomally synthesized peptides contain either one or both of the unusual amino acids meso-lanthionine (m-Lan) or β
