1532-82-7 Usage
Description
Isoquinolin-4-yl 4-methylbenzenesulfonate, also known as 4-(4-Methylbenzenesulfonate)-4-isoquinolinol, is an organic compound that serves as an impurity in the synthesis of certain pharmaceutical compounds. It is characterized by its molecular structure, which includes an isoquinolinyl group and a 4-methylbenzenesulfonate group.
Uses
Used in Pharmaceutical Synthesis:
Isoquinolin-4-yl 4-methylbenzenesulfonate is used as a synthetic intermediate for the production of 1-Phenyl-2,3-dihydroisoquinolin-4(1H)-one Hydrochloride (P309050). This intermediate is crucial in the synthesis of cis-Hydroxy Solifenacin (H953525) and cis-Hydroxy Solifenacin N-Oxide (H953485), which are metabolites of Solifenacin (S676700, HCl).
Used in Urinary Incontinence Treatment:
In the pharmaceutical industry, isoquinolin-4-yl 4-methylbenzenesulfonate plays a significant role in the development of Solifenacin, a muscarinic M3 receptor antagonist. Solifenacin is utilized in the treatment of urinary incontinence, a condition characterized by the involuntary leakage of urine. The compound's involvement in the synthesis of Solifenacin highlights its importance in contributing to the development of effective treatments for this medical condition.
Check Digit Verification of cas no
The CAS Registry Mumber 1532-82-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,5,3 and 2 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1532-82:
(6*1)+(5*5)+(4*3)+(3*2)+(2*8)+(1*2)=67
67 % 10 = 7
So 1532-82-7 is a valid CAS Registry Number.
1532-82-7Relevant articles and documents
Catalyst-Controlled Selectivity in the Synthesis of C2- and C3-Sulfonate Esters from Quinoline N-Oxides and Aryl Sulfonyl Chlorides
Ying, Beibei,Xu, Jun,Zhu, Xiaolei,Shen, Chao,Zhang, Pengfei
, p. 2604 - 2608 (2016/08/30)
The first example of the catalyst-controlled selective synthesis of C2- and C3-sulfonate-ester-substituted quinolines was developed by employing LaCl3 and chitosan@CuI catalysts, respectively. This protocol provides an expeditious route to an important class of quinoline derivatives frequently found in many biologically active compounds and features good practicality, high efficiency, and environmental friendliness. In addition, the easily recoverable chitosan@copper catalysts can be recycled five times without significant loss of catalytic performance.
