1532-91-8Relevant articles and documents
Preparation method of 4-halogenated isoquinoline compound
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Paragraph 0021-0024, (2021/08/19)
The invention relates to a preparation method of a 4-halogenated isoquinoline compound. The method comprises the following steps: adding an Ag2O catalyst, a reactant I, a reactant II, a K2S2O8 oxidant, an acetonitrile solution and magneton into a reactor, placing the reactor in an oil bath pan with the temperature of 60-100 DEG C, heating and reacting for 4-12 hours, pouring the reaction liquid into a separating funnel, adding distilled water, extracting with ethyl acetate, merging the obtained organic phases, carrying out rotary drying by using a rotary evaporator, and carrying out column chromatography separation and purification on a crude product to obtain the 4-halogenated isoquinoline compound, wherein the reactant I is isoquinoline; and the reactant II is KX, and X is halogen. The 4-halogenated isoquinoline compound is synthesized by taking an isoquinoline group as a positioning group and carrying out halogenation reaction at the No.4 site of isoquinoline. The method is mild in reaction condition, relatively high in yield and environment-friendly. Through detection, the synthesized 4-halogenated isoquinoline compound has better biological activity and can be applied to the fields of drug synthesis, pesticide synthesis, paint dye synthesis and the like.
5-Substituted isoquinoline derivatives
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Page 104, (2010/02/10)
A compound represented by the following formula (1) or a salt thereof: wherein R1 represents hydrogen atom, a halogen atom and the like; R2 represents hydrogen atom, a halogen atom, a C1-6 alkyl group and the like; and R3 represents —O—X—C(A1)(A11)—C(A2)(A2l)—N(A3l)(A3)(X represents propylene group etc., A11 and A21 represent hydrogen atom, or a C1-6 alkyl group, A31 represents a C1-6 alkyl group substituted with hydroxyl group, or hydrogen atom, and A1, A2, and A3 represent hydrogen atom, a C1-6 alkyl group and the like) and the like, which has an inhibitory activity on the phosphorylation of myosin regulatory light chain, and is useful for treatment of diseases relating to contraction of various cells and the like.
Heterocyclic Enamides Studies. I. Preparation of 4-Bromo- and 4-Chloroisoquinolines from 1,2-Dihydroisoquinoline Derivatives
Urbanski, Jerzy,Wrobel, Leszek
, p. 417 - 424 (2007/10/02)
The reactions of isoquinoline Reissert compounds analogs 1 with bromine and phosphorus pentachloride as well as the hydrolysis of enamides 1, 2 and 3 have been studied.Compounds 1 treated with bromine in most cases undergo bromination of unsaturated carbon C-4; when treated with PCl5 only 1-phenyl and 1-(2,4,6-trinitrobenzyl) derivatives undergo analogous chlorination.Acidic or basic hydrolysis of starting enamides and their 4-halogeno derivatives results in aromatization with splitting off or retention of substituents at C-1.The sequence of reactions studied can be used as a new interesting route to some 4-bromo or 4-chloroisoquinolines.