15320-91-9

Basic information

• Product Name: 2,8-dimethyl-10H-phenoxaphosphinin-10-ol 10-oxide
• CAS NO: 15320-91-9
• Molecular Formula: C₁₄H₁₃O₃P
• Molecular Weight: 260.225
• Mol File: 15320-91-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 517°C at 760 mmHg
• Flash Point: 266.5°C
• Density: 1.35g/cm³
• Vapor Pressure: 1.63E-11mmHg at 25°C
• Refractive Index: 1.633
• CAS DataBase Reference: 2,8-dimethyl-10H-phenoxaphosphinin-10-ol 10-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,8-dimethyl-10H-phenoxaphosphinin-10-ol 10-oxide(15320-91-9)
• EPA Substance Registry System: 2,8-dimethyl-10H-phenoxaphosphinin-10-ol 10-oxide(15320-91-9)

Safety Data

• Hazardous Substances Data: 15320-91-9(Hazardous Substances Data)

Usage

Phosphorus-containing heterocyclic compound

Yes, with a phenyl group attached to a phosphorus atom

Oxide

Yes, contains an oxygen atom bonded to the phosphorus

Physical state

White crystalline solid

Molecular weight

204.18 g/mol

Potential applications

Organic synthesis, as a reagent in various chemical reactions

Handling precautions

Handle with caution, as phosphorus-containing compounds can be reactive and may pose health and safety risks

Upstream product

• 106-38-7 para-bromotoluene 
• 106-44-5 p-cresol 
• 65654-60-6 (10-chloro-2,8-dimethyl-10H-phenoxaphosphine) 
• 1579-40-4 1,1'-oxybis(4-methyl-benzene) 
• 21990-64-7 2,8-dimethyl-10H-10λ⁵-phenoxaphosphine 10-oxide 

Downstream Products

• 76219-43-7 10-Benzyloxy-2,8-dimethyl-phenoxaphosphine 10-oxide 

Relevant articles and documents

Reaction of 4,4′-dimethyldiphenyl ether with phosphorus trichloride in the presence of anhydrous aluminum chloride

The reaction of 4,4′-dimethyldiphenyl ether with phosphorus trichloride in the presence of anhydrous aluminum chloride was studied. This reaction affords 2,8-dimethyl-10H-10λ5-phenoxaphosphine 10-oxide as virtually the only product. In air, the latter in an alkaline solution is quantitatively transformed into 10-hydroxy-2,8-dimethyl-10H- 10λ5-phenoxaphosphine 10-oxide.

Organophosphorus and Nitro-Substituted Sulfonate Esters of 1-Hydroxy-7-azabenzotriazole as Highly Efficient Fast-Acting Peptide Coupling Reagents

Organophosphorus esters 9, 10, 14, and 15 prepared via reaction of diethyl- and diphenylphosphoryl chloride, di(o-tolyl)phosphinyl chloride, and 2,8-dimethylphenoxaphosphinyl chloride with HOAt are excellent coupling reagents for peptide synthesis which are generally superior to their uronium/guanidinium analogues and HOBt- or HODhbt-derived phosphate ester counterparts in minimizing loss of configuration during segment coupling. The phosphinyl analogues are more shelf-stable than the phosphoryl systems. The new reagents have been tested in segment couplings leading to two tripeptides (20, 21) and a hexapeptide 22. Outstanding utility is also shown for the solid-phase assembly of the ACP decapeptide. Similar results were obtained with the 2- and 4-nitro- and 2,4-dinitrophenylsulfonyl esters derived from HOAt.