153311-52-5

Basic information

• Product Name: 5-hydroxy-1-(4-hydroxyphenyl)-3-decanone
• Synonyms: 5-hydroxy-1-(4-hydroxyphenyl)-3-decanone
• CAS NO: 153311-52-5
• Molecular Weight: 264.365
• Mol File: 153311-52-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 5-hydroxy-1-(4-hydroxyphenyl)-3-decanone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-hydroxy-1-(4-hydroxyphenyl)-3-decanone(153311-52-5)
• EPA Substance Registry System: 5-hydroxy-1-(4-hydroxyphenyl)-3-decanone(153311-52-5)

Safety Data

• Hazardous Substances Data: 153311-52-5(Hazardous Substances Data)

Upstream product

• 522617-84-1 4-(4-trimethylsilyloxyphenyl)butan-2-one 
• 66-25-1 hexanal 
• 22214-30-8 4-(4'-hydroxyphenyl)but-3-en-2-one 
• 123-08-0 4-hydroxy-benzaldehyde 
• 5471-51-2 4-(4-hydroxyphenyl)-2-oxobutane 

Relevant articles and documents

GINGEROL DERIVATIVE HAVING INHIBITORY ACTIVITY AGAINST BIOFILM FORMATION AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS EFFECTIVE INGREDIENT FOR PREVENTING OR TREATING BIOFILM-CAUSED INFECTION SYMPTOM

The present invention relates to a gingerol derivative having inhibitory activity against biofilm formation and a pharmaceutical composition for preventing or treating infections caused by biofilms including the gingerol derivative as an active ingredient. The gingerol derivative of the present invention exhibits significantly improved binding affinity for LasR and inhibitory activity against biofilm formation. Therefore, the gingerol derivative of the present invention can act on various membrane surfaces where biofilms tend to form and can effectively inhibit the formation of the corresponding biofilms. In addition, the use of the pharmaceutical composition according to the present invention can fundamentally prevent or treat a variety of infections caused by biofilms due to the presence of the gingerol derivative in the pharmaceutical composition.

Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators

In order to explore the structural determinants for the TRPV1 and TRPA1 agonist properties of gingerols, aseries of nineteen analogues (1b-5) of racemic [6]-gingerol (1a) was synthesized and tested on TRPV1 and TRPA1 channels. The exploration of the structure-activity relationships, by modulating the three pharmacophoric regions of [6]-gingerol, led to the identification of some selective TRPV1 agonists/desensitizers of TRPV1 channels (3a, 3f, and 4) and of some full TRPA1 antagonists (2c, 2d, 3b, and 3d). 2011 Elsevier Ltd. All rights reserved.