153381-94-3Relevant articles and documents
Synthesis and N-Methyl- d -aspartate (NMDA) Receptor Activity of Ketamine Metabolites
Morris, Patrick J.,Moaddel, Ruin,Zanos, Panos,Moore, Curtis E.,Gould, Todd,Zarate, Carlos A.,Thomas, Craig J.
, p. 4572 - 4575 (2017)
Ketamine is rapidly metabolized in the human body to a variety of metabolites, including the hydroxynorketamines. At least two hydroxynorketamines have significant antidepressant action in rodent models, with limited action against the N-methyl-d-aspartate (NMDA) receptor. The synthesis of 12 hydroxynorketamines and their binding affinity to the NMDA receptor is presented here.