153436-68-1

Basic information

• Product Name: 6-(BROMOMETHYL)-4-CHLOROQUINAZOLINE
• Synonyms: 6-(BROMOMETHYL)-4-CHLOROQUINAZOLINE
• CAS NO: 153436-68-1
• Molecular Formula: C₉H₆BrClN₂
• Molecular Weight: 257.51
• Mol File: 153436-68-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 363.23°C at 760 mmHg
• Flash Point: 173.476°C
• Appearance: /
• Density: 1.7g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.689
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 6-(BROMOMETHYL)-4-CHLOROQUINAZOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(BROMOMETHYL)-4-CHLOROQUINAZOLINE(153436-68-1)
• EPA Substance Registry System: 6-(BROMOMETHYL)-4-CHLOROQUINAZOLINE(153436-68-1)

Safety Data

• Hazardous Substances Data: 153436-68-1(Hazardous Substances Data)

Usage

General Description

6-(Bromomethyl)-4-chloroquinazoline is a chemical compound with the molecular formula C8H6BrClN2. It is a quinazoline derivative and contains a bromomethyl and a chloro group. 6-(BROMOMETHYL)-4-CHLOROQUINAZOLINE is commonly used as a building block in the synthesis of pharmaceuticals and other organic compounds. It is also employed in various chemical reactions and processes. The precise physical and chemical properties of 6-(Bromomethyl)-4-chloroquinazoline, as well as its potential uses and hazards, are subject to ongoing research and investigation.

InChI:InChI=1/C9H6BrClN2/c10-4-6-1-2-8-7(3-6)9(11)13-5-12-8/h1-3,5H,4H2

Upstream product

• 19181-53-4 6-methyl-4-hydroxyquinazoline 
• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 58421-79-7 4-chloro-6-methylquinazoline 

Downstream Products

• 1259017-75-8 2-((4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-quinazolin-6-yl)methyl)isoindoline-1,3-dione 
• 1259017-58-7 C₂₈H₂₆ClFN₄O₃S₂ 
• 1259017-59-8 C₂₁H₂₀ClFN₄O₂S₂ 
• 1259017-60-1 C₂₁H₂₁BrN₄O₂S₂ 
• 1259017-61-2 C₂₆H₂₁ClFN₅OS₂ 
• 1259017-62-3 C₂₇H₂₄ClFN₄O₃S₂ 
• 1259017-63-4 C₃₂H₂₈ClFN₄O₃S₃ 
• 195457-65-9 6-bromomethyl-4-(3'-methylanilino)quinazoline 

Relevant articles and documents

Novel dithiocarbamic acid esters derived from 6-aminomethyl-4- anilinoquinazolines and 6-aminomethyl-4-anilino-3-cyanoquinolines as potent EGFR inhibitors

Two series of dithiocarbamic acid esters, 4-anilinoquinazoline-6- ylmethylcarbamodithioic acid esters and 3-cyano-4-anilinoquinolin-6- ylmethylcarbamodithioic acid esters, were designed and synthesized. The effect of the synthesized compounds on cell proliferation was evaluated by MTT assay against three human cancer cell lines: MDA-MB-468, SK-BR-3 and HCT-116. Most of the compounds are equally or more potent than the positive control lapatinib. Three compounds (14d, 14h and 14i) were identified as dual inhibitors of the EGFR and ErbB-2 kinases and two compounds (14b and 14c) were identified as multi-target kinase inhibitors, and they are very worthy of further study. Installation of the dithiocarbamic acid ester group at the 6-position of 4-anilinoquinazoline or 3-cyano-4-anilinoquinoline could improve the inhibitory activity. Different dithiocarbamic acid ester groups significantly affect the activities. Two series of dithiocarbamic acid esters were designed and synthesized. Compound 14d was found to have higher biological activity than lapatinib. Some useful structure-activity relationships were revealed. Copyright

N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor Xa

This invention is directed to N-acylpyrrolidin-2-ylalkylbenzamidine derivatives which useful for inhibiting the activity of Factor Xa, by contacting said derivatives with a composition containing Factor Xa. The present invention is also directed to compos

QUINAZOLINE DERIVATIVES USEFUL FOR TREATMENT OF NEOPLASTIC DISEASE

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