153463-65-1

Basic information

• Product Name: 3,5-DICHLORO-4-PYRIDINECARBONITRILE
• Synonyms: 3,5-DICHLOROISONICOTINONITRILE;3,5-DICHLORO-4-PYRIDINECARBONITRILE;4-Cyano-3,5-dichloropyridine;3,5-dichloropyridine-4-carbonitrile;3,5-Dichloro-4-pyridinecarbonitrile
• CAS NO: 153463-65-1
• Molecular Formula: C₆H₂Cl₂N₂
• Molecular Weight: 173
• Product Categories: C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyridines
• Mol File: 153463-65-1.mol
• Article Data: 11

Chemical Properties

• Melting Point: 115-119 °C(lit.)
• Boiling Point: 266.217 °C at 760 mmHg
• Flash Point: 114.804 °C
• Appearance: /
• Density: 1.5 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -0.84±0.10(Predicted)
• CAS DataBase Reference: 3,5-DICHLORO-4-PYRIDINECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DICHLORO-4-PYRIDINECARBONITRILE(153463-65-1)
• EPA Substance Registry System: 3,5-DICHLORO-4-PYRIDINECARBONITRILE(153463-65-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41-43
• Safety Statements: 26-36/37/39
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 153463-65-1(Hazardous Substances Data)

Usage

General Description

3,5-Dichloro-4-pyridinecarbonitrile is a chemical compound with the molecular formula C6HCl2N2. It is a white to light beige solid that is insoluble in water but soluble in organic solvents. 3,5-DICHLORO-4-PYRIDINECARBONITRILE is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a building block in the production of various organic compounds. 3,5-Dichloro-4-pyridinecarbonitrile is classified as a nitrile, which is a functional group containing a carbon-nitrogen triple bond. It is important to handle this compound with caution, as it may be harmful if ingested, inhaled, or in contact with skin. Protective measures should be taken when working with this chemical, and it should be stored and disposed of properly according to industry regulations and guidelines.

Upstream product

• 70593-51-0 3,5-dichloro-4-pyridine-carboxamide 
• 183679-35-8 ethyl 3,5-dichloro-4-pyridinecarboximidate 
• 136590-83-5 3,5-dichloropyridine-4-carboxaldehyde 

Downstream Products

• 886457-32-5 3-(4-Amino-phenyl)-5-chloro-isonicotinonitrile 
• 1337533-58-0 3-chloro-5-(1-[(3-methylphenyl)acetyl]-2,3-dihydro-1H-indol-5-yl)-4-pyridinecarbonitrile 
• 1337533-74-0 3-chloro-5-(1-([3-(trifluoromethyl)phenyl]acetyl)-2,3-dihydro-1H-indol-5-yI)-4-pyridinecarbonitrile 
• 70593-51-0 3,5-dichloro-4-pyridine-carboxamide 
• 900804-00-4 3,5-dimethoxypyridin-4-amine 
• 444087-36-9 3.5-dimethoxyisonicotinic acid 

Relevant articles and documents

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Tumor angiogenesis is mediated by KDR and other VEGFR and PDGFR kinases. Their inhibition presents an attractive approach for developing anticancer therapeutics. Here, we report a series of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted k

ISOTHIAZOLOPYRIDIN-3-YLENAMINES FOR COMBATING ANIMAL PESTS

The present invention relates to lsothiazolopyridin-3-ylenamine compounds of the general formula I and to the agriculturally useful salts thereof and to compositions comprising such compounds. The invention also relates to the use of the lsothiazolopyridin-3-ylenamine compounds, of their salts or of compositions comprising them for combating animal pests. A lsothiazolopyridin-3-ylenamine compound of the present invention is represented by the following formula I:

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Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.