1535179-62-4Relevant articles and documents
Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents
Almodares, Zahra,Lucas, Stephanie J.,Crossley, Benjamin D.,Basri, Aida M.,Pask, Christopher M.,Hebden, Andrew J.,Phillips, Roger M.,McGowan, Patrick C.
, p. 727 - 736 (2014/02/14)
Novel rhodium, iridium, and ruthenium half-sandwich complexes containing (N,N)-bound picolinamide ligands have been prepared for use as anticancer agents. The complexes show promising cytotoxicities, with the presence, position, and number of halides having a significant effect on the corresponding IC50 values. One ruthenium complex was found to be more cytotoxic than cisplatin on HT-29 and MCF-7 cells after 5 days and 1 h, respectively, and it remains active with MCF-7 cells even under hypoxic conditions, making it a promising candidate for in vivo studies.
