1535186-26-5Relevant articles and documents
Protected sphingosine from phytosphingosine as an efficient acceptor in glycosylation reaction
Di Benedetto, Roberta,Zanetti, Luca,Varese, Monica,Rajabi, Mehdi,Di Brisco, Riccardo,Panza, Luigi
, p. 952 - 955 (2014)
A convenient, simple, and high-yielding five-step synthesis of a sphingosine acceptor from phytosphingosine is reported, and its behavior in glycosylation reactions is described. Different synthetic paths to sphingosine acceptors using tetrachlorophthalimide as a protecting group for the sphingosine amino function and different glycosylation methods have been explored. Among the acceptors tested, the easiest accessible acceptor, unprotected on the two hydroxyl groups in positions 1 and 3, was regioselectively glycosylated on the primary position, the regioselectivity depending on the donor used.