153681-86-8

Basic information

• Product Name: 6-chloro-1,2-dihydro-1-methyl-4-phenylquinazoline-2-carboxylic acid
• Synonyms: 6-chloro-1,2-dihydro-1-methyl-4-phenylquinazoline-2-carboxylic acid
• CAS NO: 153681-86-8
• Molecular Weight: 300.744
• Mol File: 153681-86-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-chloro-1,2-dihydro-1-methyl-4-phenylquinazoline-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-1,2-dihydro-1-methyl-4-phenylquinazoline-2-carboxylic acid(153681-86-8)
• EPA Substance Registry System: 6-chloro-1,2-dihydro-1-methyl-4-phenylquinazoline-2-carboxylic acid(153681-86-8)

Safety Data

• Hazardous Substances Data: 153681-86-8(Hazardous Substances Data)

Upstream product

• 4746-62-7 2-amino-2-hydroxyacetic acid 
• 1022-13-5 5-chloro-2-(methylamino)benzophenone 

Downstream Products

• 52395-03-6 6-chloro-1,4-dihydro-1-methyl-4-hydroxy-4-phenylquinazoline 
• 20927-53-1 6-chloro-1-methyl-4-phenyl-2(1H)-quinazolinone 

Relevant articles and documents

Reactions of hydroxyglycines. New synthetic routes to 4-phenylquinazoline derivatives

Reaction of hydroxyglycine with 2-aminobenzophenones gives 1,2-dihydro-4-phenyl-quinazoline-2-carboxylic acids in high yields and under mild conditions. These can be smoothly converted into the corresponding 3,4-dihydro isomers and into quinazoline derivatives via rearrangement and oxidation by air, respectively. The X-ray crystallographic structure of 6-chloro-1,2-dihydro-1-methyl-4-phenylquinazoline-2-carboxylic acid shows the carboxylate group at C(2) and the methyl group at N(1) to be in axial positions.