1537171-67-7

Basic information

• Product Name: 1-(4-chloro-2-hydroxyphenyl)-4-fluoro-3-(fluoromethyl)-3-hydroxybutan-1-one
• Synonyms: 1-(4-chloro-2-hydroxyphenyl)-4-fluoro-3-(fluoromethyl)-3-hydroxybutan-1-one
• CAS NO: 1537171-67-7
• Molecular Weight: 264.656
• Mol File: 1537171-67-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-chloro-2-hydroxyphenyl)-4-fluoro-3-(fluoromethyl)-3-hydroxybutan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-chloro-2-hydroxyphenyl)-4-fluoro-3-(fluoromethyl)-3-hydroxybutan-1-one(1537171-67-7)
• EPA Substance Registry System: 1-(4-chloro-2-hydroxyphenyl)-4-fluoro-3-(fluoromethyl)-3-hydroxybutan-1-one(1537171-67-7)

Safety Data

• Hazardous Substances Data: 1537171-67-7(Hazardous Substances Data)

Upstream product

• 453-14-5 1,3-difluoro-propan-2-one 
• 6921-66-0 4-chloro-2-hydroxy acetophenone 

Downstream Products

• 1537171-68-8 C₁₁H₉ClF₂O₂ 
• 1221443-94-2 (R)-1-(7-chloro-2,2-bis(fluoromethyl)-chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea 
• 1537171-71-3 (R)-7-chloro-2,2-bis(fluoromethyl)-chroman-4-aminium chloride 
• 1537171-73-5 (R)-7-chloro-2,2-bis(fluoromethyl)-chroman-4-amine (S)-5-oxopyrrolidine-2-carboxylate 

Relevant articles and documents

Asymmetric synthesis of a TRPV1 antagonist via tert -butanesulfinamide- directed reductive amination with a chromanone

An expedient asymmetric synthesis of TRPV1 antagonist 1 has been developed and demonstrated on multikilogram scale. The enabling route to 1 is detailed herein and characterized by the following key transformations: an aldol-cyclodehydration sequence to install the chromanone, and an auxiliary-mediated diastereoselective reductive amination.