15379-30-3

Basic information

• Product Name: 2',3'-dideoxy-5-fluorouridine
• Synonyms: 2',3'-dideoxy-5-fluorouridine
• CAS NO: 15379-30-3
• Molecular Formula: C₉H₁₁FN₂O₄
• Molecular Weight: 230.1930432
• Mol File: 15379-30-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.67g/cm³
• CAS DataBase Reference: 2',3'-dideoxy-5-fluorouridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2',3'-dideoxy-5-fluorouridine(15379-30-3)
• EPA Substance Registry System: 2',3'-dideoxy-5-fluorouridine(15379-30-3)

Safety Data

• Hazardous Substances Data: 15379-30-3(Hazardous Substances Data)

Usage

Property

Synthetic nucleoside analog

Property

Antiviral and anticancer potential

Property

Modified uridine structure

Property

Fluorine atom addition

Property

Inhibition of viral and cancerous DNA/RNA incorporation

Property

Activity against various viruses

Property

Activity against certain types of cancer cells

Property

Potential treatment for other viral infections and malignancies

Explanation

2',3'-dideoxy-5-fluorouridine is a man-made compound that resembles the natural nucleoside uridine.

Explanation

The compound has been studied for its ability to inhibit the replication and growth of viruses and cancer cells.

Explanation

The 2' and 3' hydroxyl groups of the natural nucleoside uridine are replaced with hydrogen in 2',3'-dideoxy-5-fluorouridine.

Explanation

A fluorine atom is added at the 5' position of the modified uridine, further altering its structure.

Explanation

The modifications in the compound's structure prevent it from being incorporated into viral or cancerous DNA or RNA, thus inhibiting their replication and growth.

Explanation

Research has shown that 2',3'-dideoxy-5-fluorouridine exhibits antiviral activity against viruses such as HIV and hepatitis B.

Explanation

The compound has demonstrated anticancer activity against specific cancer cell types.

Explanation

2',3'-dideoxy-5-fluorouridine has been investigated as a possible treatment for additional viral infections and cancer types beyond HIV, hepatitis B, and the initially studied cancer cells.

Upstream product

• 81252-58-6 Benzoic acid 5-(5-fluoro-4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 62396-80-9 (5S)-(5-tert-butyldimethylsilyloxymethyl)furan-2(5H)-one 
• 32780-06-6 (5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran 
• 21461-84-7 (2S)-tetrahydro-5-oxofuran-2-carboxylic acid 
• 56-86-0 L-glutamic acid 
• 187458-07-7 5-({[tert-butyl(dimethyl)silyl]oxy}methyl)tetrahydrofuran-2-yl acetate 

Relevant articles and documents

NMR studies of pyrimidinic nucleosides derived from 2,3-dideoxy-d-ribose with inhibitory activity on LINE-1 mobility

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Analogs of pyrimidine nucleosides. 16. Racemic 2′,3′-dideoxynucleosides and their derivatives

The chlorination of 2-halomethyltetrahydrofurans and acyl derivatives of tetrahydrofuryl alcohol wasstudied; mixtures of 2,5- and 2,2-disubstituted tetrahydrofurans are formed as a result of the reaction. 2,4-Bis(trimethylsilyl) derivatives of uracil, 5-substituted uracils, and cytosine are alkylated by the resulting mixtures of α-chloro ethers without separation, and mixtures of cis and transisomers of 1-(5-substituted-2-tetrahydrofuryl) and 1-(2-substituted-2-tetrahydrofuryl) derivatives of uracil, 5-substituted uracils, and cytosine are obtained. The reaction products were identified onthe basis of their PMR spectra.