1538576-42-9

Basic information

• Product Name: Abz-Val-Ala-Asp-Nva-Ala-Asp-Tyr-Gln-NH₂
• CAS NO: 1538576-42-9
• Molecular Weight: 998.06
• Mol File: 1538576-42-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Abz-Val-Ala-Asp-Nva-Ala-Asp-Tyr-Gln-NH₂(CAS DataBase Reference)
• NIST Chemistry Reference: Abz-Val-Ala-Asp-Nva-Ala-Asp-Tyr-Gln-NH₂(1538576-42-9)
• EPA Substance Registry System: Abz-Val-Ala-Asp-Nva-Ala-Asp-Tyr-Gln-NH₂(1538576-42-9)

Safety Data

• Hazardous Substances Data: 1538576-42-9(Hazardous Substances Data)

Upstream product

• 35661-39-3 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine 
• 112883-29-1 N-Fmoc-Tyr-OH 
• 71989-14-5 Fmoc-(tBu)Asp-OH 
• 118-92-3 anthranilic acid 
• 71989-20-3 N₂-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamine 
• 135112-28-6 Fmoc-norvaline-OH 

Relevant articles and documents

In silico design, synthesis, and assays of specific substrates for proteinase 3: Influence of fluorogenic and charged groups

Neutrophil serine proteases are specific regulators of the immune response, and proteinase 3 is a major target antigen in antineutrophil cytoplasmic antibody-associated vasculitis. FRET peptides containing 2-aminobenzoic acid (Abz) and N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) as fluorophore and quencher groups, respectively, have been widely used to probe proteases specificity. Using in silico design followed by enzymatic assays, we show that Abz and EDDnp significantly contribute to substrate hydrolysis by PR3. We also propose a new substrate specific for PR3.