153886-68-1 Usage
Description
3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonic acid is an organic compound with the molecular formula C10H13NO3S. It is a derivative of tetrahydroquinoline, featuring a methyl group at the 3rd position and a sulfonic acid group at the 8th position. 3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonic acid is known for its unique chemical properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonic acid is used as an impurity in the synthesis of Argatroban (A769000) for its role as a synthetic thrombin inhibitor and antithrombotic. Argatroban is utilized in the treatment of thrombotic disorders, and the presence of this sulfonic acid compound can affect the purity and efficacy of the final product.
Used in Chemical Research:
In the field of chemical research, 3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonic acid can be used as a starting material or intermediate for the synthesis of various complex organic molecules. Its unique structure and functional groups make it a valuable compound for exploring new chemical reactions and developing novel pharmaceuticals or other specialty chemicals.
Used in Quality Control and Analysis:
3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonic acid can also be employed in the quality control and analysis of pharmaceutical products containing Argatroban or other related thrombin inhibitors. By monitoring the levels of 3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonic acid, manufacturers can ensure the purity and quality of their products, ultimately contributing to the safety and effectiveness of the medications.
Check Digit Verification of cas no
The CAS Registry Mumber 153886-68-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,3,8,8 and 6 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 153886-68:
(8*1)+(7*5)+(6*3)+(5*8)+(4*8)+(3*6)+(2*6)+(1*8)=171
171 % 10 = 1
So 153886-68-1 is a valid CAS Registry Number.
153886-68-1Relevant articles and documents
SSR182289A, a selective and potent orally active thrombin inhibitor
Altenburger, Jean-Michel,Lassalle, Gilbert Y.,Matrougui, Mostapha,Galtier, Daniel,Jetha, Jean-Claude,Bocskei, Zsolt,Berry, Christopher N.,Lunven, Catherine,Lorrain, Janine,Herault, Jean-Pascal,Schaeffer, Paul,O'Connor, Stephen E.,Herbert, Jean-Marc
, p. 1713 - 1730 (2007/10/03)
SSR182289A 1 is the result of a rational optimisation process leading to an orally active thrombin inhibitor. The structure incorporates an original 2-(acetylamino)-[1,1′-biphenyl]-3-sulfonyl N-terminal motif, a central L-Arg surrogate carrying a weakly basic 3-amino-pyridine, and an unusual 4-difluoropiperidine at the C-terminus. Its synthesis is convergent and palladium catalysis has been employed for the construction of the key C-C bonds: Suzuki coupling for the bis-aryl fragment and Sonogashira reaction for the δ-ε bond of the central amino-acid chain. The compound is a potent inhibitor of thrombin's activities in vitro and demonstrates potent oral anti-thrombotic potencies in three rat models of thrombosis. The observed in vitro potency could be rationalized through the examination of the interactions within the SSR182289A 1 - thrombin crystal structure. SSR182289A 1, has been therefore selected for further development.
