154012-15-4

Basic information

• Product Name: 4,6-Dichloro-5-nitronicotinic acid ethyl ester
• Synonyms: 4,6-Dichloro-5-nitronicotinic acid ethyl ester;Ethyl 4,6-dichloro-5-nitronicotinate;Ethyl 4,6-dichloro-5-nitropyridine-3-carboxylate, 2,4-Dichloro-5-(ethoxycarbonyl)-3-nitropyridine
• CAS NO: 154012-15-4
• Molecular Formula: C₈H₆Cl₂N₂O₄
• Molecular Weight: 265
• EINECS: 604-604-1
• Mol File: 154012-15-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 36-38°
• Boiling Point: 352.9±37.0 °C(Predicted)
• Appearance: /
• Density: 1.533±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.86±0.10(Predicted)
• CAS DataBase Reference: 4,6-Dichloro-5-nitronicotinic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-Dichloro-5-nitronicotinic acid ethyl ester(154012-15-4)
• EPA Substance Registry System: 4,6-Dichloro-5-nitronicotinic acid ethyl ester(154012-15-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 154012-15-4(Hazardous Substances Data)

Usage

General Description

4,6-Dichloro-5-nitronicotinic acid ethyl ester is a chemical compound with the molecular formula C8H6Cl2N2O4. It is an ester derivative of 4,6-dichloro-5-nitronicotinic acid, which is a nitro-containing compound used in the synthesis of various pharmaceuticals and agrochemicals. 4,6-Dichloro-5-nitronicotinic acid ethyl ester is characterized by its yellow crystalline appearance and is soluble in organic solvents such as ethanol, acetone, and dichloromethane. It is often utilized in research and development processes in the pharmaceutical and agrochemical industries, particularly in the synthesis of new compounds with potential biological activities. Additionally, 4,6-Dichloro-5-nitronicotinic acid ethyl ester is also used as a building block for the synthesis of other more complex chemical compounds.

Upstream product

• 6975-44-6 4,6-dihydroxynicotinic acid ethyl ester 
• 105-50-0 diethyl 1,3-acetonedicarboxylate 
• 6317-97-1 ethyl 2,4-dihydroxy-3-nitropyridine-5-carboxylate 

Downstream Products

• 925546-62-9 C₁₄H₁₀ClN₃O₃ 
• 925427-26-5 sodium 4-[(3-bromophenyl)amino]-1-methyl-1H-imidazo[4,5-c]pyridine-7-carboxylate 
• 925427-28-7 4-[(2,4-dichlorophenyl)amino]-1-methyl-1H-imidazo[4,5-c]pyridine-7-carboxylic acid hydrochloride 
• 925427-31-2 4-[(3-chlorophenyl)oxy]-1-methyl-1H-imidazol[4,5-c]pyridine-7-carboxylic acid hydrochloride 
• 925427-27-6 ethyl 4-[(2,4-dichlorophenyl)amino]-1-methyl-1H-imidazo[4,5-c]pyridine-7-carboxylate 
• 925427-25-4 ethyl 4-[(3-bromophenyl)amino]-1-methyl-1H-imidazo[4,5-c]pyridine-7-carboxylate 
• 925427-29-8 ethyl 4-[(3-chlorophenyl)amino]-1-methyl-1H-imidazo[4,5-c]pyridine-7-carboxylate 
• 925427-30-1 4-[(3-chlorophenyl)amino]-1-methyl-1H-imidazo[4,5-c]pyridine-7-carboxylic acid 
• 925546-54-9 1-methyl-7-(4-morpholinylcarbonyl)-N-{3-[(trifluoromethyl)oxy]phenyl}-1H-imidazo[4,5-c]pyridin-4-amine 
• 925546-50-5 4-[(3-chlorophenyl)oxy]-1-methyl-7-(1-piperidinylcarbonyl)-1H-imidazo[4,5-c]pyridine 
• 925546-43-6 N-(2,4-dichlorophenyl)-1-methyl-7-(4-morpholinylcarbonyl)-1H-imidazo[4,5-c]pyridin-4-amine 
• 925546-39-0 N-(3-bromophenyl)-1-methyl-7-(1-piperidinylcarbonyl)-1H-imidazo[4,5-c]pyridin-4-amine 
• 925427-08-3 N-(3-chlorophenyl)-1-methyl-7-(4-morpholinylcarbonyl)-1H-imidazo[4,5-c]pyridin-4-amine 

Relevant articles and documents

Discovery and SAR study of 2-(1-propylpiperidin-4-yl)-3H-imidazo[4,5-c]pyridine-7-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) for the treatment of cancer

A series of imidazo[4,5-c]pyridine-7-carboxamide derivatives as poly(ADP-ribose) polymerase (PARP) inhibitors have been developed. All target compounds were evaluated for their PARP-1 inhibitory activity and some were further assessed for cellular potency

NEW MACROLIDES USEFUL AGAINST INFLAMMATORY AND ALLERGIC DISSEASES

Macrolide compounds of formula I: with PDF4 inhibiting activity are described, wherein R1 is a residue -Y-X-Q; Y is S, SO or SO2; X is a bond or a linear group consisting of hydrogen atoms and with up to 9 atoms selected from C, N, O and/or S,

The synthesis of a series of 7-amino-1-cyclopropyl-8-fluoro-1,4-dihydro- 4-oxo-1,6-naphthyridine-3-carboxylic acids as potential antibacterial agents

-