154026-00-3

Basic information

• Product Name: (2S,3S)-3-(2-Amino-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid 4-chloro-3-methyl-phenyl ester
• Synonyms: (2S,3S)-3-(2-Amino-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid 4-chloro-3-methyl-phenyl ester
• CAS NO: 154026-00-3
• Molecular Weight: 443.951
• Mol File: 154026-00-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3S)-3-(2-Amino-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid 4-chloro-3-methyl-phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-3-(2-Amino-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid 4-chloro-3-methyl-phenyl ester(154026-00-3)
• EPA Substance Registry System: (2S,3S)-3-(2-Amino-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid 4-chloro-3-methyl-phenyl ester(154026-00-3)

Safety Data

• Hazardous Substances Data: 154026-00-3(Hazardous Substances Data)

Upstream product

• 42245-42-1 methyl 3-(4-methoxyphenyl)glycidate 
• 105560-93-8 methyl (2R,3S)-3-(4-methoxyphenyl)glycidate 
• 59-50-7 4-Chloro-3-methylphenol 
• 137-07-5 2-amino-benzenethiol 
• 154169-78-5 (2R,3S)-3-(4-Methoxy-phenyl)-oxirane-2-carboxylic acid 4-chloro-3-methyl-phenyl ester 

Downstream Products

• 42399-49-5 (2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one 

Relevant articles and documents

First practical resolution of a 3-(4-methoxyphenyl)glycidic acid ester by preferential crystallization and synthesis of diltiazem

Among the various esters of 3-(4-methoxyphenyl)glycidic acid, 4-chloro- 3-methylphenyl ester (±)-3 was found to exist as a conglomerate, and could be alternately resolved into (+)- and (-)-3 of >98% ee by a preferential crystallization procedure. Furthermore, a 1,5-benzothiazepine derivative, (+)-6, a significant intermediate of diltiazem, was prepared in one pot in 76% overall yield through the treatment of enantiomerically pure (-)-3 with 2-aminothiophenol followed by a ring closing reaction.