154079-54-6

Basic information

• Product Name: Carbamic acid, [(1S,2S)-2,3-dihydroxy-1-methylpropyl]-, 1,1-dimethylethyl
• Synonyms: Carbamic acid, [(1S,2S)-2,3-dihydroxy-1-methylpropyl]-, 1,1-dimethylethyl
• CAS NO: 154079-54-6
• Molecular Formula: C₉H₁₉NO₄
• Molecular Weight: 205.25146
• Product Categories: N-BOC
• Mol File: 154079-54-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, [(1S,2S)-2,3-dihydroxy-1-methylpropyl]-, 1,1-dimethylethyl(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S,2S)-2,3-dihydroxy-1-methylpropyl]-, 1,1-dimethylethyl(154079-54-6)
• EPA Substance Registry System: Carbamic acid, [(1S,2S)-2,3-dihydroxy-1-methylpropyl]-, 1,1-dimethylethyl(154079-54-6)

Safety Data

• Hazardous Substances Data: 154079-54-6(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 154171-00-3 (2S,3S)-3-amino-1,2-butanediol 
• 172097-65-3 (S)-N-tert-butoxycarbonyl-1-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanamine 

Downstream Products

• 106539-14-4 (S)-methyl 3-(tert-butyloxycarbonylamino)butyrate 
• 106539-36-0 tert-butyl N-[(2S)-4-hydroxybutan-2-yl]carbamate 
• 115378-33-1 (-)-tert-butyl [(1S)-1-methylprop-2-en-1-yl]carbamate 
• 172097-54-0 (4S,5S)-N-tert-butoxycarbonyl-5-(4-methoxybenzyloxymethyl)-2,2,4-trimethyloxazolidine 
• 172097-51-7 (2S,3S)-1-p-methoxybenzyloxy-3-tertbutoxycarbonylamino-2-butanol 
• 174282-97-4 (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxybutanoic acid 
• 174282-86-1 (2S,3S)-3-tert-butoxycarbonylamino-2-hydroxybutanoic acid 
• 174282-91-8 (2R,3S)-1-tert-butyldimethylsilyloxy-3-tert-butoxycarbonylamino-2-p-nitrophenylcarbonyloxybutane 
• 174282-88-3 (2R,3S)-1-tert-butyldimethylsilyloxy-3-tert-butoxycarbonylamino-2-phenylcarbonyloxybutane 
• 174282-92-9 (2R,3S)-3-tert-butoxycarbonylamino-2-p-nitrophenylcarbonyloxy-1-butanol 
• 174282-89-4 (2R,3S)-3-tert-butoxycarbonylamino-2-phenylcarbonyloxy-1-butanol 
• 165683-90-9 (R)-1-<(S)-1-(tert-butoxycarbonylamino)ethyl>oxirane 

Relevant articles and documents

Asymmetric synthesis of ES-285, an anticancer agent isolated from marine sources

The asymmetric synthesis of (2S,3R)-2-amino-3-octane-decanol hydrochloride (ES-285-HC1) was achieved in eight steps in ca. 38% overall yield from the N-benzylimine-derived from. (R)-2,3-O-isopropylidene glyceraldehyde, which is easily available on gram sc

Stereocontrolled addition of Grignard reagents to α-alkoxy nitrones. Synthesis of syn and anti 3-amino-1,2-diols

The stereoselective addition of Grignard reagents to α-alkoxy nitrones has been achieved with excellent stereocontrol using ZnBr2 and Et2AlCl as precomplexing agents to obtain the corresponding syn- and anti- adducts, respectively. The obtained hydroxylamines have been transformed into valuable 3-amino-1,2-diols.

A convenient, stereodivergent approach to the enantioselective synthesis of N-Boc-aminoalkyl epoxides

An efficient, stereodivergent and enantioselective synthesis of N-Boc-aminoalkyl epoxides has been developed. Starting from enantiomerically enriched anti N-diphenylmethyl-3-amino-1,2-diols, and after a change in the nitrogen protecting group, an intramol