1541-26-0

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-(2-cyclohexen-1-yl)-
• CAS NO: 1541-26-0
• Molecular Formula: C14H13NO2
• Molecular Weight: 227.263
• Mol File: 1541-26-0.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-(2-cyclohexen-1-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-(2-cyclohexen-1-yl)-(1541-26-0)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-(2-cyclohexen-1-yl)-(1541-26-0)

Safety Data

• Hazardous Substances Data: 1541-26-0(Hazardous Substances Data)

Usage

Structure

A derivative of isoindole with a cyclohexenyl group attached to the 2-position of the isoindole ring.

Usage

In the synthesis of various pharmaceuticals and agrochemicals due to its potential biological activity.

Potential applications

As an anticancer and antiviral agent, as well as an inhibitor of enzyme activity.

Importance

Valuable tool for medicinal and organic chemistry research due to its chemical structure and properties.

Upstream product

• 136918-14-4 phthalimide 
• 110-83-8 cyclohexene 
• 1074-82-4 potassium phtalimide 
• 1165952-91-9 cyclohexa-1,3-diene 
• 2439-85-2 N-bromophthalimide 
• 930-68-7 cyclohexenone 
• 88-96-0 phthalamide 
• 822-67-3 Cyclohex-2-enol 
• 1521-51-3 rac-3-bromocyclohexene 

Downstream Products

• 1541-25-9 3-amino-1-cyclohexene 
• 102653-17-8 cis-3-acetamidocyclohexyl acetate 
• 106729-83-3 (1S,2R)-2-[3H-Isobenzofuran-(1Z)-ylideneamino]-cyclohexanol 
• 106729-82-2 (1R,2R,6R)-2-Bromo-6-[3H-isobenzofuran-(1Z)-ylideneamino]-cyclohexanol 
• 1403864-04-9 4-((1R,3S)-3-hydroxycyclohexylamino)-2-(methylthio)pyrimidine-5-carboxamide 
• 1403864-03-8 4-((1R,3S)-3-hydroxycyclohexylamino)-2-(methylthio)pyrimidine-5-carboxylic acid 
• 1403864-02-7 ethyl 4-((1R,3S)-3-hydroxycyclohexylamino)-2-(methylthio)pyrimidine-5-carboxylate 
• 1403860-24-1 4-(tert-butylamino)-2-(((1R,3S)-3-hydroxycyclohexyl)amino)pyrimidine-5-carboxamide 
• 1403864-22-1 (1S,3R)-3-(dibenzylamino)-1-methylcyclohexanol 
• 1403864-21-0 (1R,3R)-3-(dibenzylamino)-1-methylcyclohexanol 
• 1403864-65-2 (3R,5R)-N,N-dibenzyl-1-oxaspiro[2.5]octan-5-amine 
• 1403864-66-3 (3S,5R)-N,N-dibenzyl-1-oxaspiro[2.5]octan-5-amine 
• 1403864-24-3 (1S,3R)-3-amino-1-methylcyclohexanol 
• 1403864-57-2 2-(2-bromo-3-hydroxy-cyclohexyl)-isoindole-1,3-dione 

Relevant articles and documents

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Compound with cell proliferative resistance activity, preparation method and application

The invention relates to a compound with cell proliferative resistance activity, a preparation method and application. The invention discloses a compound with cell proliferative resistance activity, as shown in formula I, pharmaceutically acceptable salt

Copper-catalyzed oxidative dehydrogenative carboxylation of unactivated alkanes to allylic esters via alkenes

We report copper-catalyzed oxidative dehydrogenative carboxylation (ODC) of unactivated alkanes with various substituted benzoic acids to produce the corresponding allylic esters. Spectroscopic studies (EPR, UV-vis) revealed that the resting state of the catalyst is [(BPI)Cu(O2CPh)] (1-O2CPh), formed from [(BPI)Cu(PPh3)2], oxidant, and benzoic acid. Catalytic and stoichiometric reactions of 1-O2CPh with alkyl radicals and radical probes imply that C-H bond cleavage occurs by a tert-butoxy radical. In addition, the deuterium kinetic isotope effect from reactions of cyclohexane and d12-cyclohexane in separate vessels showed that the turnover-limiting step for the ODC of cyclohexane is C-H bond cleavage. To understand the origin of the difference in products formed from copper-catalyzed amidation and copper-catalyzed ODC, reactions of an alkyl radical with a series of copper-carboxylate, copper-amidate, and copper-imidate complexes were performed. The results of competition experiments revealed that the relative rate of reaction of alkyl radicals with the copper complexes follows the trend Cu(II)-amidate > Cu(II)-imidate > Cu(II)-benzoate. Consistent with this trend, Cu(II)-amidates and Cu(II)-benzoates containing more electron-rich aryl groups on the benzamidate and benzoate react faster with the alkyl radical than do those with more electron-poor aryl groups on these ligands to produce the corresponding products. These data on the ODC of cyclohexane led to preliminary investigation of copper-catalyzed oxidative dehydrogenative amination of cyclohexane to generate a mixture of N-alkyl and N-allylic products.