154179-33-6

Basic information

• Product Name: 4-(3'-hydroxyphenyl)amino-7-chloroquinoline
• Synonyms: 4-(3'-hydroxyphenyl)amino-7-chloroquinoline
• CAS NO: 154179-33-6
• Molecular Weight: 270.718
• Mol File: 154179-33-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(3'-hydroxyphenyl)amino-7-chloroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3'-hydroxyphenyl)amino-7-chloroquinoline(154179-33-6)
• EPA Substance Registry System: 4-(3'-hydroxyphenyl)amino-7-chloroquinoline(154179-33-6)

Safety Data

• Hazardous Substances Data: 154179-33-6(Hazardous Substances Data)

Upstream product

• 86-98-6 4,7-dichloroquinoline 
• 591-27-5 m-Hydroxyaniline 

Downstream Products

• 1414781-90-0 C₂₄H₂₀ClN₃O 
• 1312291-22-7 3-[(7-chloroquinolin-4-yl)amino]-2-(4-methylpiperazin-1-ylmethyl)phenol 

Relevant articles and documents

7-CHLORO-QUINOLIN-4-AMINE COMPOUNDS AND USES THEREOF FOR THE PREVENTION OR TREATMENT OF DISEASES INVOLVING FORMATION OF AMYLOID PLAQUES AND/OR WHERE A DYSFUNCTION OF THE APP METABOLISM OCCURS

The present invention relates to compounds having the following Formula (I) for use in the prevention and/or the treatment of diseases involving formation of amyloid plaques and/or where a dysfunction of the APP metabolism occurs.

Microwave-accelerated solvent- and catalyst-free synthesis of 4-aminoaryl/alkyl-7-chloroquinolines and 2-aminoaryl/alkylbenzothiazoles

An efficient synthesis of 4-aminoaryl/alkyl-7-chloroquinolines and 2-aminoaryl/alkylbenzothiazoles has been developed by microwave-accelerated regioselective aromatic nucleophilic substitution of 4,7-dichloroquinoline and 2-chlorobenzothiazole with aromatic and aliphatic amines under solvent-free conditions in the absence of any added protic or Lewis acid catalyst. Chemoselective reaction with the amino group in preference to the phenolic hydroxy group was observed. Thus, the treatment of 4,7-dichloroquinoline (1 equiv.) with a mixture of aniline (2 equiv.) and phenol (2 equiv.) afforded exclusive formation of 4-aminophenyl-7-chloroquinoline. When 4,7-dichloroquinoline (1 equiv.) was separately treated with 2-aminophenol (2 equiv.) and 4-aminophenol (2 equiv.), 4-(2'-hydroxyphenyl)-7-chloroquinoline and 4-(4'-hydroxyphenyl)-7-chloroquinoline, respectively, were formed. CSIRO 2007.