1542167-08-7

Basic information

• Product Name: tert-butyl 2-((5S,8S)-6-(tert-butoxycarbonyl)-8-(hydroxymethyl)-12,12-dimethyl-3,10-dioxo-1,1,1-triphenyl-11-oxa-2,6,9-triazatridecan-5-yl)-6-((tertbutoxycarbonyl)amino)pyrimidine-4-carboxylate
• Synonyms: tert-butyl 2-((5S,8S)-6-(tert-butoxycarbonyl)-8-(hydroxymethyl)-12,12-dimethyl-3,10-dioxo-1,1,1-triphenyl-11-oxa-2,6,9-triazatridecan-5-yl)-6-((tertbutoxycarbonyl)amino)pyrimidine-4-carboxylate
• CAS NO: 1542167-08-7
• Molecular Weight: 897.081
• Mol File: 1542167-08-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 2-((5S,8S)-6-(tert-butoxycarbonyl)-8-(hydroxymethyl)-12,12-dimethyl-3,10-dioxo-1,1,1-triphenyl-11-oxa-2,6,9-triazatridecan-5-yl)-6-((tertbutoxycarbonyl)amino)pyrimidine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-((5S,8S)-6-(tert-butoxycarbonyl)-8-(hydroxymethyl)-12,12-dimethyl-3,10-dioxo-1,1,1-triphenyl-11-oxa-2,6,9-triazatridecan-5-yl)-6-((tertbutoxycarbonyl)amino)pyrimidine-4-carboxylate(1542167-08-7)
• EPA Substance Registry System: tert-butyl 2-((5S,8S)-6-(tert-butoxycarbonyl)-8-(hydroxymethyl)-12,12-dimethyl-3,10-dioxo-1,1,1-triphenyl-11-oxa-2,6,9-triazatridecan-5-yl)-6-((tertbutoxycarbonyl)amino)pyrimidine-4-carboxylate(1542167-08-7)

Safety Data

• Hazardous Substances Data: 1542167-08-7(Hazardous Substances Data)

Upstream product

• 1257225-37-8 3-t-butyl 5-ethyl 1H-pyrazole-3,5-dicarboxylate 
• 13831-03-3 tert-butyl prop-2-ynoate 
• 1542167-17-8 3-(tert-butyl) 5-ethyl 1-amino-1H-pyrazole-3,5-dicarboxylate 
• 1542167-07-6 tert-butyl (S)-4-(((tert-butyloxycarbonyl)((S)-1-(4-(tert-butyloxycarbonyl)-6-((tertbutyloxycarbonyl)amino)pyrimidin-2-yl)-3-oxo-3-(tritylamino)propyl)amino)methyl)-2,2-dimethyloxazolidine-3-carboxylate 
• 1542167-06-5 4-(tert-butyl) 6-ethyl 2-((S)-1-((tert-butyloxycarbonyl)(((S)-3-(tert-butyloxycarbonyl)-2,2-dimethyloxazolidin-4-yl)methyl)amino)-3-oxo-3-(tritylamino)propyl)pyrimidine-4,6-dicarboxylate 
• 1542167-05-4 4-(tert-butyl) 6-ethyl 2-((S)-1-((((S)-3-(tert-butyloxycarbonyl)-2,2-dimethyloxazolidin-4-yl)methyl)amino)-3-oxo-3-(tritylamino)propyl)pyrimidine-4,6-dicarboxylate 
• 1542167-14-5 C₁₁H₁₅N₃O₄ 
• 1542166-86-8 C₃₄H₄₃N₅O₄ 
• 1542166-92-6 (S)-tert-butyl 4-((((S)-1-amino-1-(hydroxyimino)-4-oxo-4-(tritylamino)butan-2-yl)amino)methyl)-2,2-dimethyloxazolidine-3-carboxylate 
• 1542166-91-5 (S)-tert-butyl 4-((((S)-1-cyano-3-oxo-3-(tritylamino)propyl)amino)methyl)-2,2-dimethyloxazolidine-3-carboxylate 
• 1542166-90-4 (S)-tert-butyl 4-((((S)-1-amino-1,4-dioxo-4-(tritylamino)butan-2-yl)amino)methyl)-2,2-dimethyloxazolidine-3-carboxylate 
• 132388-58-0 (S)-2-Amino-N-trityl-succinamic acid 
• 95715-87-0 (R)-3-tert-butoxycarbonyl-4-formyl-2,2-dimethyloxazolidine 
• 1542166-89-1 (S)-2-((((S)-3-(tert-butyloxycarbonyl)-2,2-dimethyloxazolidin-4-yl)methyl)amino)-4-oxo-4-(tritylamino)butanoic acid 

Downstream Products

• 1542167-09-8 (S)-3-((tert-butyloxycarbonyl)((S)-1-(4-(tert-butyloxycarbonyl)-6-((tert-butyloxycarbonyl)-amino)pyrimidin-2-yl)-3-oxo-3-(tritylamino)propyl)amino)-2-((tert-butyloxycarbonyl)-amino)propanoic acid 
• 1542167-10-1 tert-butyl 2-((5S,8S)-6-(tert-butyloxycarbonyl)-8-carbamoyl-12,12-dimethyl-3,10-dioxo-1,1,1-triphenyl-11-oxa-2,6,9-triazatridecan-5-yl)-6-((tert-butyloxycarbonyl)amino)-pyrimidine-4-carboxylate 
• 1542167-12-3 2-((5S,8S)-6-(tert-butyloxycarbonyl)-8-carbamoyl-12,12-dimethyl-3,10-dioxo-1,1,1-triphenyl-11-oxa-2,6,9-triazatridecan-5-yl)-6-((tert-butyloxycarbonyl)amino)pyrimidine-4-carboxylic acid 
• 1542167-13-4 tert-butyl 4-((S)-3-(((S)-1-(tert-butyloxy)-1-oxopropan-2-yl)amino)-2-(2-((5S,8S)-6-(tertbutoxycarbonyl)-8-carbamoyl-12,12-dimethyl-3,10-dioxo-1,1,1-triphenyl-11-oxa-2,6,9-triazatridecan-5-yl)-6-((tert-butyloxycarbonyl)amino)pyrimidine-4-carboxamido)-3-oxopropyl)-1H-imidazole-1-carboxylate 

Relevant articles and documents

Total syntheses of (-)-pyrimidoblamic acid and P-3A

Total syntheses of (-)-pyrimidoblamic acid and P-3A are disclosed. Central to the convergent approach is a powerful inverse electron demand Diels-Alder reaction between substituted electron-deficient 1,2,3-triazines and a highly functionalized and chiral primary amidine, which forms the pyrimidine cores and introduces all necessary stereochemistry in a single step. Intrinsic in the convergent approach is the potential it provides for the late stage divergent synthesis of modified analogs bearing deep-seated changes in either the pyrimidine cores or the highly functionalized C2 side chain common to both natural products. The examination of the key cycloaddition reaction revealed that the inherent 1,2,3-triazine mode of cycloaddition (C4/N1 vs C5/N2) as well as the amidine regioselectivity were unaffected by introduction of two electron-withdrawing groups (-CO2R) at C4 and C6 of the 1,2,3-triazine even if C5 is unsubstituted (Me or H), highlighting the synthetic potential of the powerful pyrimidine synthesis.