154306-95-3

Basic information

• Product Name: C₅₄H₆₄Cl₆N₂O₁₈
• Synonyms: C₅₄H₆₄Cl₆N₂O₁₈
• CAS NO: 154306-95-3
• Molecular Weight: 1241.82
• Mol File: 154306-95-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₅₄H₆₄Cl₆N₂O₁₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₄H₆₄Cl₆N₂O₁₈(154306-95-3)
• EPA Substance Registry System: C₅₄H₆₄Cl₆N₂O₁₈(154306-95-3)

Safety Data

• Hazardous Substances Data: 154306-95-3(Hazardous Substances Data)

Upstream product

• 154306-89-5 (3R,4S)-3-hydroxy-4-(4-dimethylaminophenyl)-1-[(S)-1-phenyl]ethyl-2-azetidinone 
• 154306-92-0 (4S,5R)-4-(4-Dimethylamino-phenyl)-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester 
• 154306-90-8 methyl (2R,3S)-2-hydroxy-3-[(S)-1-phenyl]ethylamino-3-(4-dimethylaminophenyl)propionate 
• 154306-91-9 methyl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-(4-dimethylaminophenyl)propionate 
• 157157-65-8 (2R,3S)-3-Amino-3-(4-dimethylamino-phenyl)-2-hydroxy-propionic acid methyl ester 
• 95603-44-4 7,10-di-(2,2,2-trichloroethyloxycarbonyl)-10-deacetylbaccatin III 
• 154306-93-1 (4S,5R)-4-(4-Dimethylamino-phenyl)-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 

Relevant articles and documents

A Practical Access to Chiral Phenylisoserinates, Preparation of Taxotere Analogs

A practical diastereoselective synthesis of phenylisoserine methyl esters 8a-c is described using α-methyl-benzylamine as the chiral template of a Staudinger reaction.Optically pure diastereoisomers 6a-c were easily recovered by crystallization.After opening of these intermediate azetidinones by hydrochloric acid and methanol, regioselective cleavage of the chiral auxiliary was achieved by hydrogenation over palladium.Phenylisoserinates 8b,c were used to prepare analogs of Taxotere.