154309-48-5

Basic information

• Product Name: Benzenemethanol, a-ethenyl-3-(trifluoromethyl)-
• CAS NO: 154309-48-5
• Molecular Formula: C10H9F3O
• Molecular Weight: 202.176
• Mol File: 154309-48-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, a-ethenyl-3-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, a-ethenyl-3-(trifluoromethyl)-(154309-48-5)
• EPA Substance Registry System: Benzenemethanol, a-ethenyl-3-(trifluoromethyl)-(154309-48-5)

Safety Data

• Hazardous Substances Data: 154309-48-5(Hazardous Substances Data)

Upstream product

• 454-89-7 3-Trifluoromethylbenzaldehyde 
• 1826-67-1 vinyl magnesium bromide 

Downstream Products

• 618-97-3 1-<3-(trifluoromethyl)phenyl>propan-1-ol 
• 113048-69-4 (E)-3-(3-trifluoromethylphenyl)prop-2-en-1-ol 
• 154902-43-9 (S)-1-(meta-trifluoromethylphenyl)-2-propen-1-ol 
• 154902-44-0 (1S,2R)-1-(meta-trifluoromethylphenyl)-2,3-epoxypropan-1-ol 
• 1533-05-7 3-methyl-2-[3-(trifluoromethyl)phenyl]quinoline 
• 1620878-82-1 3-{1-[3-(trifluoromethyl)phenyl]prop-2-en-1-yl}-1H-indole 
• 1596351-16-4 (R)-2-methyl-5-oxo-5-[3-(trifluoromethyl)phenyl]pentanal 
• 1273319-38-2 N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine citrate 
• 1273319-37-1 N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine fumarate 

Relevant articles and documents

The photochemistry of ring-substituted cinnamyl acetates

The photochemistry of the (E)-cinnamyl acetates ((E)-1-aryl-3-propenyl acetates, 8a-8e) with substituents H, 4-CH3O, 3-CH3O, 4-CF3, and 3-CF3, respectively, was examined in both cyclohexane and methanol solvents. Alkene isomerization (E to Z) occurred more efficiently than other reactions and evidence is presented that this process occurs from the excited triplet state. In a slower process, 1,3-migration of the acetoxy group led to the rearranged 3-aryl-3-propenyl acetate isomers (9a-9e) as the major pathway, particularly in cylohexane. In methanol, the isomeric ethers 3-aryl-3-methoxypropene (14) and 1-aryl-3-methoxypropene (15) were formed by reaction of methanol with the photochemically generated cation. The combined yield of 14 and 15 (95% and 5%, respectively) was quantitative for the 4-methoxyphenyl compound (8b). Independent irradiations of the isomers 9a-9c demonstrated that the ethers 14 and 15 were primary photoproducts from 8 and not secondary photoproducts from 9. Fluorescence quantum yields and excited singlet state lifetimes indicated that the reactions, other than the E to Z isomerization, are from the excited singlet state.

Synthesis of Quinolines from Allylic Alcohols via Iridium-Catalyzed Tandem Isomerization/Cyclization Combined with Potassium Hydroxide

A new tandem catalytic process has been established for the synthesis of quinolines. This process utilizes the [IrCp?Cl2]2/KOH catalyzed isomerization/cyclization of allylic alcohols with 2-aminobenzyl alcohol. Both the secondary and primary allylic alcohols were investigated in this catalytic system to afford different substituted quinoline derivatives in moderate to good yields. A mechanism study showed the reaction following a tandem process integrating isomerization of allylic alcohols and oxidative cyclization of 2-aminobenzyl alcohol.

PROCESSES FOR THE PREPARATION OF CINACALCET

The present invention provides processes and intermediates for preparing cinacalcet base and pharmaceutically acceptable salts thereof.