1544578-94-0

Basic information

• Product Name: (+)-thymol 2-(4-isobutylphenyl)propionate
• Synonyms: (+)-thymol 2-(4-isobutylphenyl)propionate
• CAS NO: 1544578-94-0
• Molecular Weight: 338.49
• Mol File: 1544578-94-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (+)-thymol 2-(4-isobutylphenyl)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-thymol 2-(4-isobutylphenyl)propionate(1544578-94-0)
• EPA Substance Registry System: (+)-thymol 2-(4-isobutylphenyl)propionate(1544578-94-0)

Safety Data

• Hazardous Substances Data: 1544578-94-0(Hazardous Substances Data)

Upstream product

• 51146-56-6 (S)-ibuprofen 
• 89-83-8 thymol 
• 115588-20-0 (2S)-2-(4-isobutylphenyl)-propionyl chloride 

Relevant articles and documents

Synthesis and evaluation of antioxidant-S-(+)-ibuprofen hybrids as gastro sparing NSAIDs

Ibuprofen is one of the most popular NSAIDs for the last three decades but also known for its gastrointestinal side effects similar to other NSAIDs. To overcome this problem, we have designed and synthesized ibuprofen - antioxidant (thymol, guaiacol, eugenol, and menthol) hybrids (6-13) with and without spacer as gastro sparing agents. The hybrids have been found to be chemically stable, biolabile and exhibited retention of anti-inflammatory and analgesic activity with significant reduced ulcerogenicity as compared to the ibuprofen and ibuprofen + antioxidant physical mixture. The absence of ulcerogenicity may be attributed to antioxidants and improved physicochemical properties of these hybrid molecules.