154466-62-3

Basic information

• Product Name: 2-CHLORO-5-N-PENTYLPYRIMIDINE
• Synonyms: 2-CHLORO-5-N-PENTYLPYRIMIDINE;2-CHLORO-5-PENTYLPYRIMIDINE
• CAS NO: 154466-62-3
• Molecular Formula: C₉H₁₃ClN₂
• Molecular Weight: 184.67
• Product Categories: APIs & Intermediate;Pyrimidine
• Mol File: 154466-62-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 124°C/3mm
• Flash Point: 124°C/3mm
• Appearance: /
• Density: 1.085
• Vapor Pressure: 0.00296mmHg at 25°C
• Refractive Index: 1.504
• PKA: -1.05±0.22(Predicted)
• CAS DataBase Reference: 2-CHLORO-5-N-PENTYLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-N-PENTYLPYRIMIDINE(154466-62-3)
• EPA Substance Registry System: 2-CHLORO-5-N-PENTYLPYRIMIDINE(154466-62-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 154466-62-3(Hazardous Substances Data)

Usage

General Description

2-CHLORO-5-N-PENTYLPYRIMIDINE is a chemical compound that belongs to the pyrimidine family. It is a chlorinated derivative of pentylpyrimidine, which consists of a pyrimidine ring with a chlorine atom at position 2 and a pentyl group attached to the nitrogen atom at position 5. This chemical is used in various industrial applications, including pharmaceuticals, agrochemicals, and materials science. It has the potential to be utilized as a building block for the synthesis of more complex compounds with diverse biological activities. Its unique structure and properties make it a valuable resource for research and development in the chemical industry.

InChI:InChI=1/C9H13ClN2/c1-2-3-4-5-8-6-11-9(10)12-7-8/h6-7H,2-5H2,1H3

Upstream product

• 627-19-0 1-Pentyne 
• 64171-59-1 5-pentyl-2-pyrimidinol 
• 948560-20-1 2-amino-5-(pent-1-yn-1-yl)pyrimidine 
• 948560-12-1 2-amino-5-pentylpyrimidine 

Downstream Products

• 948560-14-3 1-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-5-[2-(5-pentylpyrimid-2-yl)ethynyl]uracil 
• 161952-58-5 2-(3,5-difluorophenyl)-5-pentylpyrimidine 
• 389121-14-6 C₁₅H₁₆F₂N₂ 
• 1268708-34-4 C₂₁H₂₂N₂ 
• 1224688-25-8 4-[difluoro(3,4,5-trifluorophenoxy)methyl]-4-(5-pentylpyrimidine-2-yl)-2',2,3,5-tetrafluoro-1,1',4',1-terphenyl 
• 1224685-30-6 4-[difluoro[(2,3',4',5'-tetrafluoro[1,1'-biphenyl]-4-yl)oxy]methyl]-4'-(5-pentylpyrimidine-2-yl)-2',3,5-trifluoro-1,1'-biphenyl 

Relevant articles and documents

Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d] pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core

Sonogashira coupling strategies were employed to synthesize new furo[2,3-d]pyrimidin-2(3H)-one (FuPyrm) 2′-deoxynucleoside analogues. Partial or complete reduction of ethyne-linked compounds afforded ethenyl-and ethyl-linked derivatives. Levels of inhibition of varicella-zoster virus (VZV), human cytomegalovirus (HCMV), a broad range of other DNA and RNA viruses, and several cancer cell lines were evaluated in cell cultures. The anti-VZV potency decreased with increasing rigidity of the side chain at C6 of the FuPyrm ring in the order dec-1-yn-1-yl dec-1-en-1-yl decan-1-yl. In contrast, compounds with a rigid ethynyl spacer between C6 of the FuPyrm ring and a 4-alkylphenyl moiety were more potent inhibitors of VZV than the corresponding derivatives with an ethyl spacer. Replacement of the phenyl moiety in 6-(4-alkylphenyl) derivatives with a pyridine ring (in either regioisomeric orientation) gave analogues with increased solubility in methanol but reduced anti-VZV potency, and replacement with a pyrimidine ring reduced the anti-VZV activity even further. The pyridine-ring-containing analogues were ～20-fold more potent inhibitors of VZV than acyclovir but were ～6-fold less potent than BVDU and ～60-fold weaker than the most active 6-(4-pentylphenyl)- substituted prototype.

Pyrimidine derivative, liquid crystal composition comprising the derivative, and liquid crystal display device fabricated by using the composition

An object of the invention is to provide liquid crystalline compounds having a comparatively high voltage holding ratio, high Δn and high Δε, and being excellent in miscibility with known liquid crystalline compounds at low temperatures; to provide liquid