154479-90-0 Usage
Description
(+)-1-(9-FLUORENYL)ETHYL CHLOROFORMATE, also known as (-)-1-(9-Fluorenyl)ethyl chloroformate, is a clear colorless liquid that is predominantly utilized as an in-capillary derivatization agent. This chemical compound plays a crucial role in the separation of amino acid (AA) derivatives through a technique called micellar electrokinetic chromatography (MEKC).
Uses
Used in Analytical Chemistry:
(+)-1-(9-FLUORENYL)ETHYL CHLOROFORMATE is used as an in-capillary derivatization agent for the separation of amino acid (AA) derivatives. The application reason is to enhance the efficiency and accuracy of amino acid analysis by improving the separation of AA derivatives in micellar electrokinetic chromatography (MEKC).
Used in Pharmaceutical Industry:
(+)-1-(9-FLUORENYL)ETHYL CHLOROFORMATE is used as a reagent in the synthesis of various pharmaceutical compounds. The application reason is its ability to facilitate the formation of specific chemical bonds and improve the overall yield of the desired products, contributing to the development of new drugs and therapies.
Used in Research and Development:
(+)-1-(9-FLUORENYL)ETHYL CHLOROFORMATE is used as a research tool in the field of biochemistry and molecular biology. The application reason is its potential to aid in the study of protein structure, function, and interactions, as well as its utility in the development of novel analytical methods and techniques for studying biological systems.
Used in Environmental Science:
(+)-1-(9-FLUORENYL)ETHYL CHLOROFORMATE is used as an analytical agent for the detection and quantification of specific environmental contaminants. The application reason is its ability to improve the sensitivity and specificity of environmental monitoring methods, enabling more accurate assessment of pollution levels and the effectiveness of remediation strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 154479-90-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,4,7 and 9 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 154479-90:
(8*1)+(7*5)+(6*4)+(5*4)+(4*7)+(3*9)+(2*9)+(1*0)=160
160 % 10 = 0
So 154479-90-0 is a valid CAS Registry Number.
InChI:InChI=1/C16H13ClO2/c1-10(19-16(17)18)15-13-8-4-2-6-11(13)12-7-3-5-9-14(12)15/h2-10,15H,1H3/t10-/m1/s1
154479-90-0Relevant articles and documents
(S)-(?)-Fluorenylethylchloroformate (FLEC); preparation using asymmetric transfer hydrogenation and application to the analysis and resolution of amines
Amin, Mohammad A.,Camerino, Michelle A.,Mountford, Simon J.,Ma, Xiao,Manallack, David T.,Chalmers, David K.,Wills, Martin,Thompson, Philip E.
, (2019/09/19)
Fluorenylethylchoroformate (FLEC) is a valuable chiral derivatisation reagent that is used for the resolution of a wide variety of chiral amines. Herein, we describe an improved preparation of (S)-(?)-FLEC using an efficient asymmetric catalytic transfer hydrogenation as the key step. We also demonstrate the application of FLEC as a chiral Fmoc equivalent for chiral resolution, with facile deprotection, of tetrahydroquinaldines, and its capacity for inducing regioselective outcomes in nitration reactions.
(+)-Fluorenylethylchloroformate (FLEC)-improved synthesis for application in chiral analysis and peptidomimetic synthesis
Camerino, Michelle A.,Chalmers, David K.,Thompson, Philip E.
, p. 2571 - 2573 (2013/06/05)
An efficient synthesis of the enantiomers of fluorenylethylchloroformate (FLEC) has been achieved that allows the routine application of the reagent for the resolution of chiral amines including unusual amino acids. The utility of the fluorenylethoxycarbonyl (Feoc) group as a chiral Fmoc equivalent, for combined resolution and protection of amino acids, in solid phase peptide synthesis is also shown.
