154480-38-3

Basic information

• Product Name: 5-[(4-chlorophenyl)methylene]amino-1,3,4-thiadiazole-2-thiol
• Synonyms: 5-[(4-chlorophenyl)methylene]amino-1,3,4-thiadiazole-2-thiol
• CAS NO: 154480-38-3
• Molecular Weight: 255.752
• Mol File: 154480-38-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 5-[(4-chlorophenyl)methylene]amino-1,3,4-thiadiazole-2-thiol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(4-chlorophenyl)methylene]amino-1,3,4-thiadiazole-2-thiol(154480-38-3)
• EPA Substance Registry System: 5-[(4-chlorophenyl)methylene]amino-1,3,4-thiadiazole-2-thiol(154480-38-3)

Safety Data

• Hazardous Substances Data: 154480-38-3(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 2349-67-9 2-Amino-5-mercapto-1,3,4-thiadiazole 

Downstream Products

• 1225440-92-5 5-(4-chlorobenzylthio)-N-[(4-chlorophenyl)methylene]amino-1,3,4-thiadiazol-2-amine 
• 1225440-86-7 5-(benzylthio)-N-[(4-chlorophenyl)methylene]amino-1,3,4-thiadiazol-2-amine 

Relevant articles and documents

Antimicrobial and antitubercular evaluation of some new 5-amino-1,3,4-thiadiazole-2-thiol derived schiff bases

In an effort to study the effect of 1,3,4-thidiazole based molecules on bacteria, fungal and tuberculosis species, we synthesized a series of Schiff bases (2a-2m) by reacting a variety of carbonyl compounds with 5-amino-1,3,4-thiadiazole-2-thiol. Molecula

An interactive human carbonic Anhydrase-II (hCA-II) receptor - pharmacophore molecular model & anti-convulsant activity of the designed and synthesized 5-amino-1,3,4-thiadiazole-2-thiol conjugated imine derivatives

New imines, derived from aromatic aldehyde, chalcones and 5-amino-1,3,4-thiadiazole-2-thiol exhibited promising anti-convulsant activity which is explained through chemo-biological interactions at receptor site producing the inhibition of human Carbonic Anhydrase-II enzyme (hCA-II) through the proposed pharmacophore model at molecular levels as basis for pharmacological activity. The compounds 5-{1-(4-Chlorophenyl)-3-[4-(methoxy-phenyl)-prop-2-en-1-ylidene]amino}-1,3,4-thiadiazole-2-thiol (2b), 5-{[1-(4-chloro-phenyl)]-3-[4-(dimethyl-amino-phenyl)-prop-2-en-1-ylidene]amino}-1,3,4-thiadiazole-2-thiol (2c) and 5-{[1-(4-chloro-phenyl)]-3-[(4-amino-phenyl)-prop-2-en-1-ylidene]amino}-1,3,4-thiadiazole-2-thiol (2f) showed 100% activity in comparison with standard Acetazolamide, a known anti-convulsant drug. The compounds 2c, 2f also passed the Rotarod and Ethanol Potentiation tests which further confirmed them to be safe in motor coordination activity and safe from generating neurological toxicity.

Syntheses of aromatic aldehyde imine derivatives of 2-thiobenzyl-1,3,4- thiadiazole and evaluation of their anticonvulsant activity

Benzyl and chlorobenzyl substituted 1,3, 4-thiadiazole imine derivatives have been prepared by refluxing aromatic aldehyde imine derivatives and benzyl chloride/4-chloro benzyl chloride in ethanolic potassium hydroxide. The structures of the compounds have been determined by spectral and chemical methods. The anticonvulsant activity has been carried out using Karl et al. method. All the reported compounds show good anticonvulsant activity wherein chlorobenzyl substituted compounds show potent anticonvulsant activity against phenytoin used as the standard reference drug. Neurotoxicity has been screened through the Rota rod and ethanol potentiation test. The compounds did not show any neurotoxicity.