154548-45-5

Basic information

• Product Name: 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER
• Synonyms: 1-Benzyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate;Ethyl 1-benzyloxycarbonyl-4-oxo-3-piperidinecarboxylate;1-O-benzyl 3-O-ethyl 4-oxopiperidine-1,3-dicarboxylate;4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER;1,3-Piperidinedicarboxylic acid, 4-oxo-, 3-ethyl 1-(phenylmethyl) ester
• CAS NO: 154548-45-5
• Molecular Formula: C₁₆H₁₉NO₅
• Molecular Weight: 305.33
• Product Categories: pharmacetical
• Mol File: 154548-45-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 446.4±45.0 °C(Predicted)
• Appearance: /
• Density: 1.238±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 11.06±0.20(Predicted)
• CAS DataBase Reference: 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER(154548-45-5)
• EPA Substance Registry System: 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER(154548-45-5)

Safety Data

• Hazardous Substances Data: 154548-45-5(Hazardous Substances Data)

Usage

General Description

4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER is a chemical compound consisting of a piperidine ring with a carbonyl group at the 4th position and two carboxylic acid groups at the 1st and 3rd positions. Additionally, it contains a benzyl ester group at the 1st position and an ethyl ester group at the 3rd position. 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER is commonly used in organic synthesis and pharmaceutical research for its potential medicinal properties. Its chemical structure and functional groups make it a versatile building block for the creation of various pharmaceutical compounds and other organic molecules in the laboratory.

Upstream product

• 41276-30-6 C₉H₁₄O₃NC₆H₅ 
• 501-53-1 benzyl chloroformate 
• 98977-34-5 1-tert-butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate 
• 4644-61-5 ethyl 4-piperidone-3-carboxylate hydrochloride 

Downstream Products

• 1207852-54-7 8-benzyl 6-ethyl 1,4-dithia-8-azaspiro[4.5]decane-6,8-dicarboxylate 

Relevant articles and documents

Synthesis and antitumor evaluation of novel 4-anilino-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate derivatives as potential EGFR inhibitors

Novel series of 4-anilino-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylates (5a–p, 7, and 8a–e) were synthesized and evaluated for their antiproliferative activity against the A549, HT29, H460, and H1975 cancer cell lines in vitro. Nine compounds (5a–c, 5i, 5j, 7, 8a, 8b, 8i) demonstrated moderate to significant cytotoxic activity with IC50 values below 18 μM on A549 cells, which were comparable to that of the reference gefitinib (IC50 = 18.44 μM). Especially, the further enzymatic analysis on epidermal growth factor receptor (EGFR), HER2, and VEGFR identified compound 5a as a promising hit that exhibited considerable potency both in cellular (IC50 = 5.67, 17.04, 11.29, and 12.65 μM, respectively) and EGFR enzymatic assays (IC50 = 14.8 nM). Compound 5a was capable of down-regulating the expression of EGFR and inhibited EGFR phosphorylation in a dose-dependent manner, representing a potential EGFR candidate for further optimization.

6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS

The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, their synthesis, and their use as CHK-1 inhibitors.

Immunopotentiator agents

Novel compounds and methods for preparing same, immunopotentiating compositions, and a method for potentiating the immune system of a host animal. The method comprises administering to the animal an effective amount of an immunopotentiating compound of Formula I or Formula II, or a physiologically acceptable salt.