154592-40-2Relevant articles and documents
Visible-light-promoted carboimination of unactivated alkenes for the synthesis of densely functionalized pyrroline derivatives
Cai, Sai-Hu,Xie, Jia-Hao,Song, Shengjin,Ye, Lu,Feng, Chao,Loh, Teck-Peng
, p. 5571 - 5574 (2016)
An efficient strategy which integrates visible-light-induced iminyl-radical formation with carboimination of unactivated alkenes has been developed for the easy access of densely functionalized pyrroline derivatives. With fac-[Ir(ppy)3] as photoredox catalyst, the acyl oximes were converted into iminyl radical intermediates by one electron reduction, and evolve through a cascade of intramolecular cyclization and intermolecular carbon radical trapping to give the functionalized pyrrolines. The utilization of silyl enol ethers as coupling partners not only allows the introduction of synthetically useful ketone functionalities but also renders catalyst regeneration without any external reductants. This protocol is characterized by its mild reaction conditions and the tolerance of a broad range of functionalities.
Method for synthesizing 2-methyl-5-phenyl-3,4-dihydro-2H-pyrrole compound
-
Paragraph 0016-0018, (2019/07/29)
The invention discloses a method for synthesizing a 2-methyl-5-phenyl-3,4-dihydro-2H-pyrrole compound. the method comprises the following steps: adding gamma,delta-unsaturated oxime ether, samarium metal and iodine by one-pot method into a reaction contai
Acceptorless Dehydrogenative Coupling Using Ammonia: Direct Synthesis of N-Heteroaromatics from Diols Catalyzed by Ruthenium
Daw, Prosenjit,Ben-David, Yehoshoa,Milstein, David
supporting information, p. 11931 - 11934 (2018/09/27)
The synthesis of N-heteroaromatic compounds via an acceptorless dehydrogenative coupling process involving direct use of ammonia as the nitrogen source was explored. We report the synthesis of pyrazine derivatives from 1,2-diols and the synthesis of N-substituted pyrroles by a multicomponent dehydrogenative coupling of 1,4-diols and primary alcohols with ammonia. The acridine-based Ru-pincer complex 1 is an effective catalyst for these transformations, in which the acridine backbone is converted to an anionic dearomatized PNP-pincer ligand framework.