154607-00-8 Usage
Description
2-Bromo-5-hydroxybenzoic acid Methyl ester, also known as Methyl 2-Bromo-5-hydroxybenzoate, is an organic compound derived from hydroxybenzoic acid. It is characterized by the presence of a bromine atom at the 2nd position and a hydroxyl group at the 5th position, with a methyl ester functional group. 2-broMo-5-hydroxybenzoic acid Methyl ester exhibits unique chemical properties that make it suitable for various applications in different industries.
Uses
Used in Pharmaceutical Industry:
2-Bromo-5-hydroxybenzoic acid Methyl ester is used as a key intermediate in the synthesis of macrocyclic Mcl-1 inhibitors. These inhibitors are designed for the treatment of multiple myeloma, a type of blood cancer. The compound plays a crucial role in the development of novel therapeutic agents that target the Mcl-1 protein, which is overexpressed in multiple myeloma cells and contributes to the resistance of these cells to apoptosis.
In the pharmaceutical industry, 2-Bromo-5-hydroxybenzoic acid Methyl ester is used as a building block for the creation of macrocyclic Mcl-1 inhibitors. These inhibitors are specifically designed to target and inhibit the Mcl-1 protein, which is overexpressed in multiple myeloma cells and plays a significant role in the resistance of these cells to apoptosis. By inhibiting Mcl-1, these macrocyclic compounds can potentially enhance the effectiveness of current treatments for multiple myeloma and improve patient outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 154607-00-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,6,0 and 7 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 154607-00:
(8*1)+(7*5)+(6*4)+(5*6)+(4*0)+(3*7)+(2*0)+(1*0)=118
118 % 10 = 8
So 154607-00-8 is a valid CAS Registry Number.
154607-00-8Relevant articles and documents
A Chan-Evans-Lam approach to trisubstituted vinyl ethers
Molder, Bryce A.,Sader, Jonathan K.,Wulff, Jeremy E.
supporting information, p. 9649 - 9653 (2021/12/01)
Trisubstituted vinyl ethers were accessedviaChan-Evans-Lam coupling of vinyl trifluoroborates and primary aliphatic alcohols. This approach complements prior methods that required the use of neat liquid alcohol coupling partners. A palladium-catalyzed redox-relay Heck reaction was used to convert several vinyl ethers into aldehyde-functionalized 1,3-dihydroisobenzofurans.
Concise Synthesis of a Potential 5-Lipoxygenase Activating Protein (FLAP) Inhibitor and Its Analogs through Late-Stage Alkene Dicarbofunctionalization
Kc, Shekhar,Dhungana, Roshan K.,Aryal, Vivek,Giri, Ramesh
, p. 1686 - 1694 (2019/07/04)
We report a five-step synthesis of the biologically important 1,1-diarylalkane 1, a potential 5-lipoxygenase activating protein (FLAP) inhibitor that was synthesized previously in 12 steps. In this synthesis, we apply a three-component alkene dicarbofunct
A pH-sensitive near-infrared fluorescent probe with alkaline p: K a for chronic wound monitoring in diabetic mice
Mai, Hengtang,Wang, Yu,Li, Shuang,Jia, Ruizhen,Li, Sixian,Peng, Qian,Xie, Yan,Hu, Xiang,Wu, Song
supporting information, p. 7374 - 7377 (2019/06/27)
A pH-sensitive near-infrared fluorescent probe with alkaline pKa, AlkaP-1, was developed by incorporating a benzoyl hydrazine group into a cyanine dye. The significant fluorescence changes in the alkaline regions enable the probe to monitor the alkalization process from acute wounds to chronic wounds in diabetic mice.
