154672-63-6

Basic information

• Product Name: L-Glutamic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 5-(1,1-dimethylethyl) 1-(phenylmethyl) ester
• Synonyms: Benzyl ester of α-N-(9-fluorenylmethoxycarbonyl)-γ-tert-butyl ester of L-glutamic acid;Nα-Fmoc-Glu(t-Bu)-OBzl
• CAS NO: 154672-63-6
• Molecular Formula: C31H33NO6
• Molecular Weight: 515.606
• Mol File: 154672-63-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: L-Glutamic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 5-(1,1-dimethylethyl) 1-(phenylmethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Glutamic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 5-(1,1-dimethylethyl) 1-(phenylmethyl) ester(154672-63-6)
• EPA Substance Registry System: L-Glutamic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 5-(1,1-dimethylethyl) 1-(phenylmethyl) ester(154672-63-6)

Safety Data

• Hazardous Substances Data: 154672-63-6(Hazardous Substances Data)

Upstream product

• 71989-18-9 Fmoc-Glu(OtBu)-OH 
• 100-39-0 benzyl bromide 
• 100-51-6 benzyl alcohol 

Downstream Products

• 154672-64-7 Benzyl ester of α-N-(9-fluorenylmethoxycarbonyl)-γ-N<2-(trimethylsilyl)ethoxy>amide of L-glutamic acid 
• 1053693-02-9 (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-5-(2-trimethylsilanyl-ethoxyamino)-pentanoic acid benzyl ester 
• 122350-52-1 (4S)-5-benzyloxy-4-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxopentanoic acid 

Relevant articles and documents

ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF

The invention provides anti-VISTA antibody drug conjugates which may be used for targeted delivery of anti-inflammatory agents such as steroids to immune cells, e.g., myeloid cells. The invention also provides methods of using anti-VISTA antibody drug conjugates in the treatment of inflammatory and/or autoimmune conditions and/or for alleviating the toxicity of anti-inflammatory agents such as steroids.

A new synthesis of N(α),N(δ)-protected N(δ)-hydroxycycloornithine and its homologue from an L-glutamic acid derivative

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