154748-67-1 Usage
Description
1-[(4-Hydrazinophenyl)methyl]-1H-1,2,4-triazole hydrochloride is an organic compound with the chemical formula C10H10N5?HCl. It is a white crystalline solid that is soluble in water and has a molecular weight of 240.66 g/mol. 1-[(4-Hydrazinophenyl)methyl]-1H-1,2,4-triazole hydrochloride is known for its potential applications in the pharmaceutical and chemical industries due to its unique chemical structure and properties.
Uses
Used in Pharmaceutical Industry:
1-[(4-Hydrazinophenyl)methyl]-1H-1,2,4-triazole hydrochloride is used as a reagent for the preparation of pyrazolylbenzyltriazoles, which are dual anti-inflammatory and antimicrobial agents. These agents are valuable in the development of new drugs to treat various inflammatory and infectious diseases.
1-[(4-Hydrazinophenyl)methyl]-1H-1,2,4-triazole hydrochloride is also used as a reagent in the synthesis of cyclooxygenase inhibitors. Cyclooxygenase (COX) is an enzyme involved in the production of prostaglandins, which are responsible for inflammation, pain, and fever. Inhibiting COX activity can help in the treatment of these conditions, making this compound an important tool in the development of anti-inflammatory medications.
Check Digit Verification of cas no
The CAS Registry Mumber 154748-67-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,7,4 and 8 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 154748-67:
(8*1)+(7*5)+(6*4)+(5*7)+(4*4)+(3*8)+(2*6)+(1*7)=161
161 % 10 = 1
So 154748-67-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H11N5.ClH/c10-13-9-3-1-8(2-4-9)5-14-7-11-6-12-14;/h1-4,6-7,13H,5,10H2;1H
154748-67-1Relevant articles and documents
CONVERSION OF AROMATIC DIAZONIUM SALT TO ARYL HYDRAZINE
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Page/Page column 6-7, (2008/06/13)
The present invention relates to the preparation of aryl hydrazines and their salts by treating aryl diazonium salts with triphenyl phosphine followed by hydrolysis of the resulting triphenyl-aryl hydrazyl phosphonium salt to get aryl hydrazine or its sal
PROCESS FOR PREPARING RIZATRIPTAN
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Page 12-13; 15, (2008/06/13)
In particular, rizatriptan or a pharmaceutically acceptable salt thereof, which includes a) Preparation of the diazonium salt of the aniline hydrochloride (II); followed by reduction and acidification to give the hydrazine (III); b) reaction in situ of the hydrazine hydrochloride (III) with α-keto-δ-valerolactone, to give the hydrazone (IV); c) Fischer indole reaction of the hydrazone (IV), to give the pyranoindolone (V), optionally followed by a hydrolysis reaction to give (VI); d) Transesterification of (V) or esterification of its hydrolysis product (VI), to give (VII), where R means straight or branched C1-C4 alkyl chain; e) Conversion of the hydroxyl group of (VII) into dimethylamino, to give the indolecarboxylate (VIII), where R has the meaning defined above; f) Saponification of the 2-carboalkoxy group of (VIII) to give indolecarboxylic acid (IX); and g) Decarboxylation of the indolecarboxylic acid (IX) to give rizatriptan and, eventually, to obtain a pharmaceutically acceptable salt thereof. The invention also relates to synthesis intermediates to obtain rizatriptan.
