1549536-42-6Relevant articles and documents
Hydroxypropyl substituted nitrogen bridgehead fused cyanopyridines
Milokhov, Demyd S.,Khilya, Olga V.,Turov, Alexander V.,Medviediev, Volodymyr V.,Shishkin, Oleg V.,Volovenko, Yulian M.
, p. 1214 - 1222 (2014/02/14)
The reaction of 2-hetaryl-2-(tetrahydro-2-furanyliden)acetonitriles with substituted acetonitriles as C-nucleophiles has been investigated and the mechanism of the reaction has been suggested. A base promoted Michael addition of the substituted acetonitriles to 2-hetaryl-2-(tetrahydro-2-furanyliden) acetonitriles followed by ring transformations has provided novel convenient synthetic methods to nitrogen bridgehead fused cyanopyridines bearing hydroxypropyl side chain. The structures of obtained compounds have been established based on NMR spectroscopy investigation and X-ray diffraction data.