155-11-3 Usage
Description
2,4-Pyrimidinediamine, 5-fluoro(9CI) is a pyrimidine derivative that is fluorinated at the 5-position. It is a chemical compound with potential applications in the pharmaceutical industry, particularly as a building block for the synthesis of various drugs. 2,4-Pyrimidinediamine, 5-fluoro(9CI) is known for its potential as an antitumor and antiviral agent, as well as its possible use as an anti-inflammatory and immunosuppressive agent. However, further research is needed to fully understand its biological activities and potential toxicity for safe and effective pharmaceutical use.
Uses
Used in Pharmaceutical Industry:
2,4-Pyrimidinediamine, 5-fluoro(9CI) is used as a building block for the synthesis of various drugs due to its potential antitumor and antiviral properties.
Used in Antitumor Applications:
2,4-Pyrimidinediamine, 5-fluoro(9CI) is used as an antitumor agent, with potential applications in the development of drugs targeting cancer cells.
Used in Antiviral Applications:
2,4-Pyrimidinediamine, 5-fluoro(9CI) is used as an antiviral agent, with potential applications in the development of drugs targeting viral infections.
Used in Anti-inflammatory Applications:
2,4-Pyrimidinediamine, 5-fluoro(9CI) is used as an anti-inflammatory agent, with potential applications in the development of drugs targeting inflammation-related conditions.
Used in Immunosuppressive Applications:
2,4-Pyrimidinediamine, 5-fluoro(9CI) is used as an immunosuppressive agent, with potential applications in the development of drugs targeting autoimmune diseases and transplant rejection.
Check Digit Verification of cas no
The CAS Registry Mumber 155-11-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,5 and 5 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 155-11:
(5*1)+(4*5)+(3*5)+(2*1)+(1*1)=43
43 % 10 = 3
So 155-11-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H5FN4/c5-2-1-8-4(7)9-3(2)6/h1H,(H4,6,7,8,9)
155-11-3Relevant articles and documents
Synthesis of 5-Fluorocytosine Using 2-Cyano-2-fluoroethenolate as a Key Intermediate
Dietz, Jule-Philipp,Derstine, Brenden P.,Ferenc, Dorota,Crawford, Evan T.,Arduengo, Anthony J.,Gupton, B. Frank,McQuade, D. Tyler,Opatz, Till
, p. 5519 - 5526 (2019)
There is an urgent demand for 5-fluorocytosine (5-FC) due to its activity against HIV-induced fungal infections as well as its use as a key intermediate in the synthesis of the clinically highly important anti-HIV drug emtricitabine (FTC). We report a simple, low-cost five steps synthesis of 5-FC starting from chloroacetamide. Overall yields up to 46 % were achieved and the route is devoid of any chromatographic purifications. The previously unknown key intermediate (Z)-2-cyano-2-fluoroethenolate is obtained through a Claisen-type condensation from fluoroacetonitrile. As the direct cyclization with urea only gave poor yields, 5-fluoro-2-methoxypyrimidin-4-amine, 5-fluoro-2-(methylsulfanyl)pyrimidin-4-amine and 5-fluoropyrimidine-2,4-diamine served as synthetic intermediates.
2-CYANO-2-FLUOROETHENOLATE SALTS (CFES): VERSITILE ACTIVE PHARMACEUTICAL INTERMEDIATES
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Paragraph 0010, (2020/08/30)
The present invention relates to new enolate structures with utility as active pharmaceutical intermediates for the preparation of efficacious drugs such as those derived from 5-fluorocytosine (5-FC).
