155140-18-4

Basic information

• Product Name: N?(2?hydroxybenzylidene)?4?aminobenzenesulfonic acid sodium salt
• Synonyms: N?(2?hydroxybenzylidene)?4?aminobenzenesulfonic acid sodium salt
• CAS NO: 155140-18-4
• Molecular Weight: 299.282
• Mol File: 155140-18-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N?(2?hydroxybenzylidene)?4?aminobenzenesulfonic acid sodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: N?(2?hydroxybenzylidene)?4?aminobenzenesulfonic acid sodium salt(155140-18-4)
• EPA Substance Registry System: N?(2?hydroxybenzylidene)?4?aminobenzenesulfonic acid sodium salt(155140-18-4)

Safety Data

• Hazardous Substances Data: 155140-18-4(Hazardous Substances Data)

Upstream product

• 90-02-8 salicylaldehyde 
• 121-57-3 4-aminobenzene sulfonic acid 

Downstream Products

• 32787-84-1 (E)-N-(2-hydroxybenzylidene)-4H-1,2,4-triazol-4-amine 

Relevant articles and documents

Engineering solid-state molecular switches: N-salicylidene N-heterocycle derivatives

A supramolecular engineering approach has been developed for a novel family of N-salicylidene aniline derivatives to control their thermo- and photochromic behaviours. Hsaltrz, Habs, Hsalphen, Hsaltz and Ksaltz are versatile molecules built from N-heteroc

Design, synthesis, and biological activity of Schiff bases bearing salicyl and 7-hydroxycoumarinyl moieties

Abstract: 18 (11 novel) Schiff bases, derivatives of salicylaldehyde, 2-hydroxyacetophenone, and 6-acetyl-, 8-acetyl-, and 8-formyl-7-hydroxy-4-methylcoumarin were synthesized and characterized by their spectral studies. 6-Acetyl-7-hydroxy-4-methylcoumarin was prepared by novel method under microwave assistance. These Schiff bases were evaluated for antibacterial activities against 12 bacterial and six fungi strains in vitro. N-(3,5-Dichloro-2-hydroxybenzylidene)-4-aminobenzenesulfonic acid sodium salt proved to be the most active against Staphylococcus aureus and MRSA strains (MIC 0.0194?μmol/cm3). The substitution pattern, two chlorine atoms in the salicylidene ring and the SO3Na group, is probably the most beneficial for the activity against Gram-(+) bacteria strains. All Schiff bases were evaluated for cancer efficacy against CFPAC-1 and HeLa cell cultures originating from human pancreas cancer or human cervical cancer. Schiff bases derived from salicylaldehyde are highly effective in pancreas and cervical cancer cells; however, they demonstrate also substantial toxicity towards NIH3T3 cells. Derivatives of coumarin contain three highly selective compounds: 7-hydroxy-8-[(4-methoxyphenylimino)methyl]-4-methyl-2H-chromen-2-one, N-[(7-hydroxy-4-methyl-2-oxo-2H-chromen-8-yl)methylene]-4-aminobenzenesulfonic acid sodium salt, and 7-hydroxy-8-[1-(4-hydroxyphenylimino)ethyl]-4-methyl-2H-chromen-2-one suggesting more promising potential of the second group of substances.