155153-78-9 Usage
Description
(2R,4S)-N-ALPHA-CARBOBENZOXY-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID is a carboxylic acid derivative featuring a pyrrolidine ring with a carboxylic acid group at position 2 and a benzoxy group at the nitrogen position. The 2R,4S stereochemistry denotes the specific configuration of the chiral centers in the molecule, which is crucial for its potential applications in various fields.
Uses
Used in Organic Synthesis:
(2R,4S)-N-ALPHA-CARBOBENZOXY-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID serves as a versatile building block in organic synthesis, allowing for the creation of a wide range of chemical compounds. Its unique structure and functional groups enable it to participate in various chemical reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (2R,4S)-N-ALPHA-CARBOBENZOXY-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID is utilized as a key intermediate in the development of new drugs and biologically active molecules. Its specific stereochemistry and functional groups can be exploited to design molecules with desired pharmacological properties, such as selectivity, potency, and bioavailability.
Used in Research and Development:
(2R,4S)-N-ALPHA-CARBOBENZOXY-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID is also employed in research and development settings to explore its potential applications in various fields. Scientists can use this compound to study its chemical properties, reactivity, and interactions with other molecules, which can lead to the discovery of new applications and insights into its behavior.
Overall, (2R,4S)-N-ALPHA-CARBOBENZOXY-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID is a valuable chemical compound with diverse applications in organic synthesis, pharmaceutical development, and research. Its unique structure and stereochemistry make it an attractive candidate for further exploration and utilization in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 155153-78-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,5,1,5 and 3 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 155153-78:
(8*1)+(7*5)+(6*5)+(5*1)+(4*5)+(3*3)+(2*7)+(1*8)=129
129 % 10 = 9
So 155153-78-9 is a valid CAS Registry Number.
155153-78-9Relevant articles and documents
EP300/CREBBP INHIBITOR
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Paragraph 0233; 0234, (2020/05/30)
The present invention provides a compound having excellent histone acetyltransferase inhibitory activity against EP300 and/or CREBBP, or a pharmacologically acceptable salt thereof. The compound is represented by the following formula (1) or a pharmacologically acceptable salt thereof: wherein ring Q1, ring Q2, R1, R2, R3 and R4 respectively have the same meanings as defined in the specification.
HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES
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Page/Page column 48, (2012/03/26)
The present teachings relate to compounds of Formula (I): and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, R4, R5, ring A, and Z are as defined herein
Synthesis and evaluation of lysophosphatidylserine analogues as inducers of mast cell degranulation. Potent activities of lysophosphatidylthreonine and its 2-deoxy derivative
Iwashita, Masazumi,Makide, Kumiko,Nonomura, Taro,Misumi, Yoshimasa,Otani, Yuko,Ishida, Mayuko,Taguchi, Ryo,Tsujimoto, Masafumi,Aoki, Junken,Arai, Hiroyuki,Ohwada, Tomohiko
experimental part, p. 5837 - 5863 (2010/03/24)
In response to various exogenous stimuli, mast cells (MCs) release a wide variety of inflammatory mediators stored in their cytoplasmic granules and this release initiates subsequent allergic reactions. Lysophosphatidylserine (lysoPS) has been known as an exogenous inducer to potentiate histamine release from MCs, though even at submicromolar concentrations. In this study, through SAR studies on lysoPS against MC degranulation, we identified lysoPT, a threonine-containing lysophospholipid and its 2-deoxy derivative as novel strong agonists. LysoPT and its 2-deoxy derivative induced histamine release from MCs both in vitro and in vivo at a concentration less than one-tenth that of lysoPS. Notably, lysoPT did not activate a recently proposed lysoPS receptor on MCs, GPR34, demonstrating the presence of another undefined receptor reactive to both lysoPS and lysoPT that is involved in MC degranulation. Thus, the present strong agonists, lysoPT and its 2-deoxy derivative, will be useful tools to understand the mechanisms of lysoPS-induced activation of degranulation of MCs. 2009 American Chemical Society.
