15516-43-5

Basic information

• Product Name: (2-methylphenoxy)acetyl chloride
• Synonyms: (2-methylphenoxy)acetyl chloride;acetyl chloride, (2-methylphenoxy)-
• CAS NO: 15516-43-5
• Molecular Formula: C₉H₉ClO₂
• Molecular Weight: 184.61956
• Mol File: 15516-43-5.mol
• Article Data: 29

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-methylphenoxy)acetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2-methylphenoxy)acetyl chloride(15516-43-5)
• EPA Substance Registry System: (2-methylphenoxy)acetyl chloride(15516-43-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 15516-43-5(Hazardous Substances Data)

Usage

Description

(2-methylphenoxy)acetyl chloride is a chemical compound that features a phenyl ring with a methyl group attached to it, and an acetyl chloride group (CH3COCl) connected to the phenyl ring. It is recognized for its potent acylating properties and is commonly employed as a reagent in organic synthesis, especially for the acylation of organic compounds. Due to its high reactivity and corrosive nature, it is crucial to handle this compound with caution to prevent severe burns and irritation to the skin, eyes, and respiratory tract.

Uses

Used in Organic Synthesis:
(2-methylphenoxy)acetyl chloride is used as an acylating agent for introducing acetyl groups into various substrates. Its strong acylating properties make it a valuable reagent in the synthesis of a wide range of organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (2-methylphenoxy)acetyl chloride is utilized as a key intermediate in the synthesis of various drugs and pharmaceutical agents. Its ability to acylate organic compounds allows for the creation of new molecules with potential therapeutic applications.
Used in Chemical Research:
(2-methylphenoxy)acetyl chloride is also employed in chemical research as a reagent for studying the reactivity and properties of acetyl chloride groups in different chemical contexts. This helps researchers to better understand the mechanisms of acylation reactions and develop new synthetic strategies.
Used in Material Science:
In the field of material science, (2-methylphenoxy)acetyl chloride can be used as a precursor to develop new materials with specific properties. Its acylation capabilities can be harnessed to modify the structure and function of various materials, potentially leading to advancements in areas such as polymer chemistry and materials engineering.

Upstream product

• 79-37-8 oxalyl dichloride 
• 1878-49-5 o-methylphenoxyacetic acid 
• 2989-17-5 methyl 2-methylphenoxy acetate 
• 95-48-7 ortho-cresol 
• 79-11-8 chloroacetic acid 
• 13078-21-2 ethyl 2-(2-methoxyphenoxy)acetate 
• 1878-85-9 (2-methoxyphenoxy)acetic acid 
• 90-05-1 2-methoxy-phenol 
• 4549-72-8 sodium o-cresolate 

Downstream Products

• 122594-61-0 o-tolyloxy-acetic acid-(1-ethyl-3-dimethylamino-1-phenyl-propyl ester) 
• 76596-62-8 1-chloro-3-(o-tolyloxy)propan-2-one 
• 131253-20-8 o-tolyloxy-acetic acid-(2-diethylamino-ethylamide); hydrochloride 
• 64994-72-5 2-(4-methoxy-phenyl)-5-o-tolyloxyacetyl-5H-oxazolo[4,5-b]phenoxazine 
• 137537-09-8 1-Benzoimidazol-1-yl-2-o-tolyloxy-ethanone 
• 85063-06-5 2-(o-methyl phenoxymethyl)-8-iodo anthranil 
• 86149-00-0 o-Tolyloxy-thioacetic acid S-(8-bromo-4-oxo-3-p-tolyl-3,4-dihydro-quinazolin-2-yl) ester 
• 86148-95-0 o-Tolyloxy-thioacetic acid S-[8-bromo-3-(4-bromo-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-yl] ester 
• 83142-61-4 1-(chloromethoxy)-2-methylbenzene 
• 106967-76-4 (Z)-3-Methylamino-2-(2-o-tolyloxy-acetyl)-but-2-enoic acid ethyl ester 
• 330950-54-4 C₂₄H₂₂N₂O₃ 
• 7542-40-7 4-(o-Tolyloxy-acetoxy)-cumarin 
• 129803-41-4 C₁₈H₃₁NO₅Si 
• 86149-01-1 o-Tolyloxy-thioacetic acid S-[6,8-dibromo-3-(4-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-yl] ester 

Relevant articles and documents

Design and Synthesis of Novel 4-Hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one Derivatives for Use as Herbicides and Evaluation of Their Mode of Action

In order to develop a novel herbicide containing the β-triketone motif, a series of 4-hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one derivatives were designed and synthesized. The bioassay results showed that compound II15 had good pre-emergent herbicidal activity even at a dosage of 187.5 g ha-1. Moreover, compound II15 showed a broader spectrum of weed control when compared with a commercial herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), and displayed good crop safety to Triticum aestivum L. and Zea mays Linn. when applied at 375 g ha-1 under pre-emergence conditions, which indicated its great potential as a herbicide. More importantly, studying the molecular mode of action of compound II15 revealed that the novel triketone structure is a proherbicide of its corresponding phenoxyacetic acid auxin herbicide, which has a herbicidal mechanism similar to that of 2,4-D. The present work indicates that the 4-hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one motif may be a potential lead structure for further development of novel auxin-type herbicides.

Isoflavone amide derivatives, their preparation method and medical use

The invention belongs to the field of medicinal chemistry, and relates to derivatives of isoflavones amides, as well as a preparation method and medical application of derivatives, in particular to the derivatives of the isoflavones amides with the general formula of (I) shown as the specification, the preparation method and the medical application of the derivatives, particularly the application of the derivatives of the isoflavones amides serving as medicaments for preventing or treating hyperlipemia, adiposis or type-II diabetes.

Formononetin derivatives and preparation methods and medical application thereof

The invention relates to the field of pharmaceutical chemistry, and relates to formononetin derivatives and preparation methods and medical application thereof, in particular to formononetin derivatives with the general formula as shown in (I), preparation methods thereof, pharmaceutical compositions containing the compounds and medical application of the derivatives and the pharmaceutical compositions, particularly, application of the derivatives and the pharmaceutical compositions serving as drugs for preventing or treating hyperlipidaemia or obesity or type-II diabetes. Please see the formula in the description.