155302-28-6

Basic information

• Product Name: 4-(1H-Indol-3-yl)piperidine-1-carboxylic acid tert-butyl ester
• Synonyms: 4-(1H-Indol-3-yl)piperidine-1-carboxylic acid tert-butyl ester;t-Butyl-4-(1H-indol-3-yl)piperidine-1-carboxylate
• CAS NO: 155302-28-6
• Molecular Formula: C₁₈H₂₄N₂O₂
• Molecular Weight: 300.4
• Mol File: 155302-28-6.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 460.5±38.0 °C(Predicted)
• Appearance: /
• Density: 1.149
• Storage Temp.: 2-8°C
• PKA: 17.06±0.30(Predicted)
• CAS DataBase Reference: 4-(1H-Indol-3-yl)piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1H-Indol-3-yl)piperidine-1-carboxylic acid tert-butyl ester(155302-28-6)
• EPA Substance Registry System: 4-(1H-Indol-3-yl)piperidine-1-carboxylic acid tert-butyl ester(155302-28-6)

Safety Data

• Hazardous Substances Data: 155302-28-6(Hazardous Substances Data)

Usage

General Description

4-(1H-Indol-3-yl)piperidine-1-carboxylic acid tert-butyl ester is a compound with the molecular formula C21H25N3O2. It is a tert-butyl ester derivative of piperidine-1-carboxylic acid, which contains an indole ring. This chemical is commonly used in organic synthesis as an intermediate in the production of pharmaceuticals and agrochemicals. It is also used as a building block for the synthesis of various biologically active compounds. The tert-butyl ester group in this compound provides stability and protection for the carboxylic acid, making it a useful reagent in organic chemistry.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 17403-09-7 3-(4-piperidinyl)-1H-indole 
• 345235-80-5 tert-butyl-4-(5-chloro-1H-indol-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate 
• 17422-32-1 5-chloro-1H-indole 
• 120-72-9 indole 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 155302-27-5 3-[N-(t-butyloxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-indole 

Downstream Products

• 1201648-28-3 4-[1-(Toluene-4-sulfonyl)-1H-indol-3-yl]-piperidine-1-carboxylic acid tert-butyl ester 
• 855775-78-9 tert-butyl 4-[1-[4-(methylsulfonyl)benzyl]-1H-indol-3-yl]-1-piperidinecarboxylate 
• 60155-63-7 4-(1H-indol-3-yl)piperidinium chloride 
• 1443248-77-8 4-(1H-indol-3-yl)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide 
• 17403-09-7 3-(4-piperidinyl)-1H-indole 
• 393508-48-0 4-(1-benzenesulfonyl-1H-indol-4-yl)-piperazine-1-carboxylic acid tert-butyl ester 
• 855775-21-2 4-(1-(phenylsulfonyl)-1H-indol-3-yl)piperidinium chloride 
• 855775-84-7 C₂₅H₃₀N₂O₂ 
• 855775-87-0 tert-butyl 4-[1-[4-(trifluoromethyl)benzoyl]-1H-indol-3-yl]-1-piperidinecarboxylate 
• 855776-16-8 tert-butyl 4-(1-(phenylsulfonyl)-1H-indol-3-yl)piperidine-1-carboxylate 

Relevant articles and documents

HETEROCYCLIC COMPOUND, APPLICATION THEREOF, AND COMPOSITION CONTAINING SAME

A heterocyclic compound represented by formula XI, a pharmaceutically acceptable salt, a solvate, or a solvate of a pharmaceutically acceptable salt thereof, use thereof, and a composition containing the same. The compound is novel in structure and has good STAT5 inhibitory activity.

Substituted heterocyclic compounds and its application on the medicament (by machine translation)

The invention relates to substituted heterocyclic compounds and its application on the medicament, in particular to a novel class of substituted heterocyclic compounds or its isomer, tautomer, nitrogen oxide, hydrate, solvate, metabolite, pharmaceutically acceptable salt or prodrug, and their method of preparation. The invention also relates to the compounds of the invention pharmaceutical composition, and said compound or pharmaceutical compositions for the treatment5-HT6receptor-related diseases, in particular Alzheimer's disease in the use thereof. (by machine translation)

4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: Urea-based analogs

A new series of urea-based, 4-bicyclic heteroaryl-piperidine derivatives as potent SCD1 inhibitors is described. The structure-activity relationships focused on bicyclic heteroarenes and aminothiazole-urea portions are discussed. A trend of dose-dependent decrease in body weight gain in diet-induced obese (DIO) mice is also demonstrated.