155488-25-8

Basic information

• Product Name: N-[(3R)-1-(3,3-Dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5-(2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-N'-[3-(methylamino)phenyl]urea
• Synonyms: N-[(3R)-1-(3,3-Dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5-(2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-N'-[3-(methylamino)phenyl]urea;Sograzepide;Estradiol-3-O-sulfamate;1-[(3R)-1-(3,3-dimethyl-2-oxobutyl)-2-oxo-5-pyridin-2-yl-3H-1,4-benzodiazepin-3-yl]-3-[3-(methylamino)phenyl]urea
• CAS NO: 155488-25-8
• Molecular Formula: C₂₈H₃₀N₆O₃
• Molecular Weight: 498.58
• EINECS: 604-604-1
• Mol File: 155488-25-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 723.049 °C at 760 mmHg
• Flash Point: 391.086 °C
• Appearance: /
• Density: 1.25
• PKA: 11.38±0.40(Predicted)
• CAS DataBase Reference: N-[(3R)-1-(3,3-Dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5-(2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-N'-[3-(methylamino)phenyl]urea(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(3R)-1-(3,3-Dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5-(2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-N'-[3-(methylamino)phenyl]urea(155488-25-8)
• EPA Substance Registry System: N-[(3R)-1-(3,3-Dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5-(2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-N'-[3-(methylamino)phenyl]urea(155488-25-8)

Safety Data

• Hazardous Substances Data: 155488-25-8(Hazardous Substances Data)

Usage

Description

N-[(3R)-1-(3,3-Dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5-(2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-N'-[3-(methylamino)phenyl]urea is a complex organic compound with a chemical structure that includes a benzodiazepine core and a urea linkage. It is characterized by its unique arrangement of atoms and functional groups, which may contribute to its potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
N-[(3R)-1-(3,3-Dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5-(2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-N'-[3-(methylamino)phenyl]urea is used as a pharmaceutical compound for its potential therapeutic properties. The specific application reason is not provided in the materials, but given its chemical structure, it may have potential uses in the development of drugs targeting various medical conditions.
Used in Research and Development:
In the field of research and development, this compound may be used as a starting material or a tool to study the effects of its chemical structure on biological activity. The application reason is to explore its potential interactions with biological targets and to understand its pharmacological properties, which could lead to the discovery of new therapeutic agents.
Used in Gastric Carcinoids Treatment:
As mentioned in the provided materials, Sograzepide, which shares a similar chemical structure, is used in the treatment of gastric carcinoids or patients with chronic atrophic gastritis. Therefore, N-[(3R)-1-(3,3-Dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5-(2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-N'-[3-(methylamino)phenyl]urea may also be used as a gastric receptor antagonist for similar applications.

Upstream product

• 42471-56-7 2-(2-aminobenzoyl)pyridine 
• 99-05-8 meta-aminobenzoic acid 
• 186086-59-9 [1-(3,3-Dimethyl-2-oxo-butyl)-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester 
• 164343-31-1 (R)-3-Amino-1-(3,3-dimethyl-2-oxo-butyl)-5-pyridin-2-yl-1,3-dihydro-benzo[e][1,4]diazepin-2-one 
• 168162-32-1 3-[N-(tert-butoxycarbonyl)-N-methyl-amino]phenyl isocyanate 
• 168162-30-9 3-(N-tert-butoxycarbonyl-N-methyl-amino)-benzoic acid 
• 168162-22-9 (3RS)-Amino-1-(tert-butylcarbonylmethyl)-2,3-dihydro-5-(pyridin-2-yl)-1H-1,4-benzodiazepin-2-one 
• 152665-84-4 1,3-dihydro-5-(pyridin-2-yl)-3(R,S)-[(benzyloxycarbonyl)-amino]-2H-1,4-benzodiazepin-2-one 
• 111331-82-9 3-[(tert-butoxycarbonyl)amino]benzoic acid 

Relevant articles and documents

Benzodiazepine derivatives useful as CCK-receptor antagonists

This invention relates to benzodiazepine derivatives which are useful as drugs exhibiting antagonism at the gastrin and/or CCK-B receptor, and to their production.